Objective Primary myelofibrosis (PMF) is one of the Philadelphia negative myeloproliferative neoplasms (MPN). The main clinical features are obvious physical symptoms and symptomatic splenomegaly. It may be converse to leukemia and has a shortened life expectancy. Nowadays, the therapy for PMF is aimed at maintaining comfort and there is no curative treatment. PMF with myelodysplastic syndrome ...

spindle cell neoplasms are defined as neoplasms that consist of spindle-shaped cells in the histopathology. spindle cell neoplasms can affect the oral cavity. in the oral cavity, the origin of the spindle cell neoplasms may be traced to epithelial, mesenchymal and odontogenic components. this article aims to review the spindle cell neoplasms of the oral cavity with emphasis on histopathology.  ...

Myeloid leukemias are a broad group of hematological disorders, characterized by heterogeneous clinical and biological features. In recent years, unprecedented genetic discoveries clinical–biological correlations have revolutionized the field myeloid leukemias. The most relevant changes specifically occurred in acute leukemia (AML), chronic myelomonocytic (CMML), (CML) neoplasms (MNs) with eosi...

The myelodysplastic/myeloproliferative diseases (MDS/MPDs) are a heterogeneous group of myeloid neoplasms that share characteristics with chronic myeloproliferative diseases and myelodysplastic syndromes. The broad spectrum of clinical manifestations makes MDS/MPDs extremely difficult to diagnose and treat, with a median survival time of 1-5 years. No single gene defect has been firmly associat...

Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are hematological disorders characterized by both proliferative and dysplastic features. According to the 2022 International Consensus Classification (ICC), MDS/MPN consists of clonal monocytosis undetermined significance (CMUS), chronic myelomonocytic leukemia (CMML), atypical myeloid (aCML), with SF3B1 mutation (MDS/MPN-T-SF3B1), ring sid...

BACKGROUND Alterations in the DNA methylation pattern are a hallmark of leukemias and lymphomas. However, most epigenetic studies in hematologic neoplasms (HNs) have focused either on the analysis of few candidate genes or many genes and few HN entities, and comprehensive studies are required. METHODOLOGY/PRINCIPAL FINDINGS Here, we report for the first time a microarray-based DNA methylation...

Spindle cell neoplasms are defined as neoplasms that consist of spindle-shaped cells in the histopathology. Spindle cell neoplasms can affect the oral cavity. In the oral cavity, the origin of the spindle cell neoplasms may be traced to epithelial, mesenchymal and odontogenic components. This article aims to review the spindle cell neoplasms of the oral cavity with emphasis on histopathology. ...

Currently, there is an increase in the number of publications, devoted to problem multiple primary tumors — neoplasms that occur simultaneously (synchronously) or alternately (metachronously), developing independently and each other within same different organs. They are described as two, three more nosologies. Due presence defects immune system chronic lymphocytic leukemia, solid localization ...