BACKGROUND Living cells can be viewed as complex adaptive systems that exhibit non-linear dynamics and fractal features. We investigated the fractal qualities of normal and malignant hematological cells and their potential as a tool for characterizing cell phenotype and clinical behavior. METHODS A mathematical algorithm and an optic tool for fractal analysis of nuclei were developed. A total...

Hematopoiesis is the process of blood cell formation starting from hematopoietic stem/progenitor cells (HSPCs). The understanding of regulatory networks involved in hematopoiesis and their impact on gene expression is crucial to decipher the molecular mechanisms that control hematopoietic development in physiological and pathological conditions, and to develop novel therapeutic strategies. An i...

The number of patients of reproductive age diagnosed with various malignant hematological diseases increases every year. These patients undergo chemotherapy, radiotherapy, and various other treatments that may have gonadotoxic effects. The life expectancy of these patients is increasing rapidly due to the variety of treatment options. As such, an increasing number of patients-as well as their p...

Certain patients with antibody-mediated autoimmune disease exhibit poor responses to conventional immunosuppression, including B-cell depletion with rituximab. Proteasome inhibitors such as bortezomib demonstrate pleiotropic immunomodulatory effects, including direct toxicity to antibody-producing cells. Here, we report preliminary evidence for the efficacy of bortezomib as salvage therapy for ...

We observed 71 febrile, neutropenic episodes in 25 oncohematological patients after chemotherapy during a 3-years period from 1995 to 1997. Three patients died because of infections (pneumonia with septic shock, gram-negative bacteremia and sepsis, pseudomembranous colitis and diffuse peritonitis) at the period of prolonged, deep neutropenia (absolute neutrophil count < 100/mm3). During the 71 ...

Background Inactive HBV carriers, under immunosuppressive treatment for malignancies or rheumatologic diseases, have an increased risk for HBV reactivation. HBV reactivation under immunosuppression has a high rate of acute liver failure and death. HBV screening is mandatory for patients with hematological malignancies or rheumatologic diseases who are due to receive immunosuppressive treatment.

Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) has been increasingly used in the treatment of malignant and nonmalignant hematopoietic diseases [1]. Patients with malignant diseases that cannot be controlled by conventional means or in whom treatment failure is expected are candidates for allo-HSCT [2,3]. AlloHSCT is a highly aggressive and demanding medical therapy that profoun...

Objective Vitamin B12 deficiency is a common condition in childhood and various neurological, hematological, dermatological findings could be seen due to its deficiency. The aim of the study evaluate hematological children diagnosed with vitamin Materials Methods Hematological data who were examined Pediatric Hematology Department retrospectively reviewed. Results one hundred twenty-four patien...

Background: Osteoporosis in children has various underlying causes related to hereditary or secondary to different diseases like: hematological diseases, gastrointestinal diseases, renal diseases, endocrine diseases, druginduced and immobilization. Objective: To investigate the causes of osteoporosis in pediatrics age group presented to pediatric clinic in King Abdulaziz University Hospital. Me...

Hematopoietic stem cell transplantation (HSCT) has a half-century history. It is currently an indispensable treatment for not only incurable blood diseases such as aplastic anemia and severe hemolytic anemia, but also malignant hematological diseases such as leukemia and lymphoma. Although allergenic HSCT is also used to treat hereditary diseases, its indica‐ tions are restricted because of cri...