Patients with cancer frequently have anemia, with or without other associated cytopenias. Cancer-related anemia can be a direct result of tumor invasion of the bone marrow, an indirect result of tumor therapy or systemic symptomatology, or an "incidental" finding resulting from other pathology in the patient. In many cancer cases, anemia may cause the presenting symptoms, and hematologic abnorm...

Tumor lysis syndrome is an oncologic emergency that usually occurs after chemotherapy in patients with hematologic malignancies. Tumor lysis syndrome is rare in cases of solid tumors, especially when it occurs spontaneously. Herein, we present a case of spontaneous tumor lysis syndrome in a 55-year-old woman who presented with dyspnea and was found to have extensive metastatic small cell lung c...

ABSTRACT: To determine the association between ocular abnormalities and hematologic findings in Ehrlichia canis-infected dogs, 120 dogs suspected of canine ehrlichiosis were studied. All patients subjected to rapid serologic diagnostic test for canis, diagnosis was confirmed by quantitative PCR. PCR-positive underwent ophthalmologic examination a hemogram grouped into with thrombocytopenia anem...

A 27-year-old womanwas admitted for further examination of thrombocytopenia. Symptomswere absent, but physical examination demonstrated hepatosplenomegaly without neurological abnormalities. Bone marrow examination revealed many Gaucher cells, and glucocerebrosidase activity from cultured skin fibroblasts was markedly reduced. A 1448C (L444P) mutation was detected on one allele of the glucocere...

Numerical and structural chromosomal abnormalities are common in hematological malignancies. Near-triploidy (58-80 chromosomes) is a numerical abnormality observed in 3% of adult cases of acute lymphoblastic leukemia. Near-triploidy is rare in myeloid lineage hematologic malignancies and compared to near-triploidy in lymphoid malignancies, near-triploidy in myeloid malignancies is associated wi...

Among the hematologic malignancies, the clinical and biologic significance of chromosome abnormalities have been most extensively studied in the acute leukemias and chronic myelogenous leukemia (CML). Clonal chromosome abnormalities are now identified in essentially all cases of CML and in most cases of acute nonlymphoblastic leukemia (ANLL) and acute lymphoblastic leukemia (ALL). In the acute ...