Acute onset of organ failure in heatstroke is triggered by rhabdomyolysis of skeletal muscle. Here, we showed that elevated temperature increases free cytosolic Ca2+ [Ca2+]f from RYR (ryanodine receptor)/UNC-68 in vivo in the muscles of an experimental model animal, the nematode Caenorhabditis elegans This subsequently leads to mitochondrial fragmentation and dysfunction, and breakdown of myofi...

Ordering composite hypotheses in a Bayesian network based on its associated a posteriori probabilities can be exponentially hard. This paper discusses a qualitative reasoning approach which reduces the computational complexity of deriving a partial ordering of composite hypotheses. Such a reasoning makes use of the meta-knowledge about the causal relationships among individual hypotheses to ded...

This study assesses heatstroke risk in the near future (2031–2050) under RCP8.5 scenario. The developed model is based on a generalized linear with number of ambulance transport due to (hereafter patients heatstroke) as explained variable and daily maximum temperature or wet bulb globe (WBGT) explanatory variable. With temperature, we performed projection case considering only climate change (C...

Abstract Heatstroke is a life-threatening illness related to systematic inflammation-induced multiple organ dysfunction. The severity of inflammatory response may be the changes in immune regulation triggered by heat acclimation. However, mechanisms acclimation and its effect on are unclear. Here, we assessed differences immunocyte subsets spleen lymph nodes heat-acclimated mice. Higher frequen...

A rise in intracellular sodium ion concentration ([Na+]i) was predicted by Hubbard in his "energy depletion mechanism" of heatstroke [ l ] but such rises have not been clearly shown. In this study, we have found rises in [Na+]i at elevated temperatures in isolated human squamous epithelial cells, by measuring changes in the fluorescence of a Na+-sensitive fluorophore which had been introduced i...

" tropical" diseases under the following headings:? (l)due to protozoa; (2) due to bacteria; (3) due to filterable viroses ; (4) food deficiency diseases ; (5) helminthic infections; (6) Infectious granulomata; (7) skin diseases; and (8) tropical diseases of disputed nature or minor importance among which are Peruvian Wart; Oroya fever; heatstroke and heat prostration; river fever; spotted feve...