Submit Manuscript | http://medcraveonline.com Abbreviations: APP: Acute Phase Proteins; CAT: Catalase; EVHL: Evaporative Heat Loss; FAO: Food and Agricultural Organisation; GDP: Gross Domestic Product; GPX: Glutathione peroxidise; Hp: Haptoglobin; HS: Heat Stress; HSE: Heat Shock Element; HSF: Heat Shock Factor; HSP: Heat Shock Protein; IFN: Interferon; IL: Interleukin; MDA: Malondialdehyde; NO...

Oxidative stress has been ascribed a role in the pathogenesis of diabetes and its complications, and stress proteins have been shown to protect organisms in vitro and in vivo against oxidative stress. To study the putative role of one of the most abundant cytoprotective stress proteins, inducible cytoplasmic 72-kDa-mass heat shock protein (Hsp-72), in the pathogenesis of diabetes, we measured i...

Parasitoid wasps inject their eggs into host along with virulent factors to manipulate hosts physiology and immune system. Heat shock proteins (HSPs) are as molecular chaperones and stress proteins induced by heat, cold, anoxia and parasitism. There was no report about the roles of HSP in insect eggs against egg parasitoids. Here, we studied the expression profiles of several HSPs in silkworm e...

The heat-shock response of Streptococcus pyogenes following exposure to elevated growth temperatures, and the immunological reactivity of heat-shock proteins (HSPs) in streptococcal infections were studied. Two major proteins of 65 and 75 kDa were expressed when a S. pyogenes strain was shifted from 37 degrees C to heat-shock temperatures of 40, 42 and 45 degrees C. Such proteins are members of...

A cDNA clone homologous to HeLa cell mRNA encoding the 70 kDa human heat shock protein (hsp 70) was used to isolate a recombinant phage containing an entire human hsp 70 gene. Sequence analysis of the 5' and 3' flanking regions revealed the structural integrity of the regulatory elements. The functional integrity of this hsp 70 gene was substantiated by in vitro transcription studies with nucle...

Organisms in natural habitats must frequently respond to changes in their environments through various physiological mechanisms. My laboratory has developed several methods for the quantification of stress in crustaceans. An ELISA was developed for the crustacean hyperglycemic hormone (CHH) from the American lobster (Homarus americanus). It is sensitive to as little as 0.2 fmol of peptide. Incr...

Folding of polypeptides in the cell typically requires the assistance of a set of proteins termed molecular chaperones. Chaperones are an essential group of proteins necessary for cell viability under both normal and stress conditions. There are several chaperone systems which carry out a multitude of functions all aimed towards insuring the proper folding of target proteins. Chaperones can ass...

Background. Environmental and patho-physiologic stresses stimulate synthesis of heat shock proteins (HSPs) which enable the cell to survive and recover from stressful conditions, by as yet incompletely understood mechanisms. Heat shock proteins show an increased expression in a wide range of human cancers and have been associated with tumor cell proliferation, differentiation, invasion, metasta...

When eukaryotic cells are exposed to elevated temperatures they respond by vigorously synthesizing a small group of proteins called the heat shock proteins. An essential element in defining the role of these proteins is determining whether they are unique to a stressed state or are also found in healthy, rapidly growing cells at normal temperatures. To date, there have been conflicting reports ...

Heat shock proteins (Hsps) are highly conserved proteins that play a role in cytoprotection and maintaining intestinal homeostasis. Glutamine is essential for the optimal induction of intestinal epithelial Hsp expression, but its mechanisms of action are incompletely understood. Glutamine is a substrate for polyamine synthesis and stimulates the activity of ornithine decarboxylase (ODC), a key ...