Non-penetrating injuries of the chest wall can give rise to a variety of cardiac lesions. The extent of cardiac damage depends on the intensity of the injury and on pre-existent disease of the heart. In the majority of cases there is a direct blow to the anterior chest wall but serious myocardial damage has been produced by blows directed against the posterior chest wall and abdomen. The crushi...

Poly (ADP-ribose) polymerase (PARP) has been proposed to play an important role in the pathogenesis of heart ischaemia/reperfusion (I/R) injury. However, the mechanisms of PARP-mediated heart I/R injury in vivo are still not thoroughly understood. Therefore, in this study, we investigate the effect of PARP inhibition on heart I/R injury and try to elucidate the underlying mechanisms. Studies we...

Despite the latest advances in cardiovascular biology and medicine, myocardial infarction (MI) remains one of major causes deaths worldwide. While reperfusion myocardium is critical to limit ischemic damage typical a MI event, it detrimental morphological functional changes known as “reperfusion injury.” This complex scenario poorly represented currently available models ischemia/reperfusion in...

Non-penetrating injuries of the chest wall can give rise to a variety of cardiac lesions. The extent of cardiac damage depends on the intensity of the injury and on pre-existent disease of the heart. In the majority of cases there is a direct blow to the anterior chest wall but serious myocardial damage has been produced by blows directed against the posterior chest wall and abdomen. The crushi...