Angiotensin converting enzyme inhibitors are established treatment for hypertension and heart failure. There are well documented differences between ACE inhibitors both in physicochemical properties and pharmacokinetics. Pharmacodynamic actions are similar for most members of the ACE inhibitor class but there are compounds with additional effects which may reflect protease inhibition or non-enz...

background: interventional cardiology procedures such as coronary angiography (ca) and percutaneous transluminal coronary angiography (ptca) has been increased recent years. the purpose of this study was to measurement of effective dose to cardiology staffs who operate near the patient and are exposed to non-uniform radiation field due to patient scattered radiation. materials and methods: this...

BACKGROUND The influence of changes in heart rate on myocardial contractility (the force-frequency effect) differs under various experimental conditions, including the anesthetized versus the conscious state. METHODS AND RESULTS To assess the influence of beta-adrenergic stimulation on force-frequency effects on myocardial contraction and relaxation, seven instrumented conscious dogs were stu...

background: inclusion of inhomogeneity corrections in intensity modulated small fields always makes conformal irradiation of lung tumor very complicated in accurate dose delivery. objective: in the present study, the performance of five algorithms via monte carlo, pencil beam, convolution, fast superposition and superposition were evaluated in lung cancer intensity modulated radiotherapy planni...

BACKGROUND Angiotensin-converting enzyme (ACE) inhibitors reduce heart failure death and hospitalization. Prescribed doses often are lower than randomized clinical trial (RCT) targets and practice guideline recommendations. OBJECTIVE To assess the cost-effectiveness of high- versus low-dose ACE inhibitor therapy in the ATLAS trial. STUDY DESIGN A 19-nation RCT of high-dose (32.5-35.0 mg/day...

background: we aimed to compare field-in-field technique (fif) with conformal tangential field radiotherapy (crt) in terms of dosimetric benefits for early stage breast cancer radiotherapy. materials and methods: twenty consecutive left-side breast cancer patients who underwent breast-conserving surgery were included to the study. for each patient, two different treatment plans were created for...

coronary heart disease is the leading cause of death and disability in adults. the association between acute coronary syndrom (acs) and elevated serum high sensitivity c-reactive protein (hscrp) suggests that chronic inflammation of the coronary arterial wall may play an important role. a number of drugs used in the treatment of cardiovascular disease reduce serum crp. it* is therefore possible...

PURPOSE To quantify the radiation doses received by the heart and coronary arteries from contemporary tangential breast or chest wall radiotherapy. METHODS AND MATERIALS Fifty consecutive patients with left-sided breast cancer and 5 consecutive patients with right-sided breast cancer treated at a large United Kingdom radiotherapy center during the year 2006 were selected. All patients were ir...