Background Hypopharyngeal cancer is one of the most frequent head and neck cancers associated with a poor prognosis because recurrence metastases. Therefore, there need to improve prognosis, which requires identification prognostic factors elucidation mechanisms involved in tumor progression. Accumulated evidence has demonstrated that cluster differentiation 147 (CD147) strongly expressed malig...

BACKGROUND Hypoxia is a negative prognostic factor and this study investigated the relationship between hypoxia, hypoxia inducible factor 1 (HIF-1) and AKT signaling in head and neck squamous cell carcinoma (HNSCC) and non-small-cell lung cancer (NSCLC). RESULTS/METHODOLOGY pAKT was induced by hypoxia (0.5% O2) in a part of HNSCC (3/4) and squamous (2/3) and adenocarcinoma (1/3) NSCLS lines. ...

PURPOSE Although promoter hypermethylation has been an accepted means of tumor suppressor gene inactivation, activation of otherwise normally repressed proto-oncogenes by promoter demethylation has been infrequently documented. EXPERIMENTAL DESIGN In this study we performed an integrative, whole-genome analysis for discovery of epigenetically activated proto-oncogenes in head and neck cancer ...

BACKGROUND Cetuximab is a targeted therapy with demonstrated efficacy in the management of head and neck squamous cell carcinoma (HNSCC). However, no laboratory assay is available to predict its efficacy in an individual patient. METHODS Short-term cultures of tumor slices were performed on 9 tumor samples obtained after surgical resection in patients. Cancer cell proliferation was evaluated ...

Despite advances in the treatment of head and neck squamous cell carcinoma (HNSCC), morbidity remains at a high level due to resistance SCC cells chemotherapeutics. This study aimed determine compare magnitude flavonoids’ effectiveness activating apoptosis migration arrest HNSCC vitro. Methods: Head Detroit 562 line were exposed range concentrations (5–100 μM) quercetin (Que), hesperidin (Hes) ...

AIM To evaluate the generation and repair of DNA double strand breaks (DSBs) as a critical factors that define the efficiency of radiation therapy of cancer patients. METHODS Peripheral blood lymphocytes obtained from 18 patients with head and neck squamous cell carcinoma (HNSCC) and 18 healthy donors were studied. The efficiency of DSBs repair after genotoxic treatment with hydrogen peroxide...

High-throughput molecular profiling approaches have emerged as precious research tools in the field of head and neck translational oncology. Such approaches have identified and/or confirmed the role of several genes or pathways in the acquisition/maintenance of an invasive phenotype and the execution of cellular programs related to cell invasion. Recently published new-generation sequencing stu...

Background: The diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) map and the dynamic contrast-enhanced magnetic resonance (DCE-MRI) constitute functional MRI technique many oncological applications as it can define tissue microstructure characterize post-treatment changes from a recurrent tumor in treated head neck squamous cell carcinoma (HNSCC). Objective: To evaluat...

The current literature fully supports HPV (human papillomavirus)-associated OPSCC (oropharyngeal squamous cell carcinoma) as a unique clinical entity. It affects an unambiguous patient population with defined risk factors, has a genetic expression pattern more similar to cervical squamous cell carcinoma than non-HPV-associated HNSCC (head and neck squamous cell carcinoma), and may warrant diver...

To date, cetuximab is the only anti‑epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) approved for targeted therapy of head and neck squamous cell carcinoma (HNSCC). However, this has left an eloquent number patients with recurrence local or/and distance failures, which are associated Erb‑B2 tyrosine kinase 2 (ERBB2) signaling. The dual targeting (EGFR/ERBB2) irreversible covale...