MapReduce as a service enjoyswide adoption in commercial clouds today [3,23]. Butmost cloud providers just deploy native Hadoop [24] systems on their cloud platforms to provide MapReduce services without any adaptation to these virtualized environments [6,25]. In cloud environments, the basic executing units of data processing are virtual machines. Each user’s virtual cluster needs to deploy HD...

Adipose‑derived stem cells (ADSCs) are known to secrete various cytokines, which affect fibroblast function through paracrine effects. In the present study, the paracrine effects of ADSCs on the function and senescence of young and aged human dermal fibroblasts (HDFs) were investigated in vitro. ADSCs and HDFs were isolated from healthy donors and flow cytometry was used for immunophenotype ide...

A Storage Architecture for Data-Intensive Computing by Jeffrey Shafer The assimilation of computing into our daily lives is enabling the generation of data at unprecedented rates. In 2008, IDC estimated that the “digital universe” contained 486 exabytes of data [9]. The computing industry is being challenged to develop methods for the cost-effective processing of data at these large scales. The...

Considering the various pharmacological activities of epigallocatechin-3-O-gallate (EGCG) including anticancer, and anti-inflammatory, antidiabetic, and so forth, relatively less attention has been paid to the antiaging effect of EGCG on primary cells. In this study, the preventive effects of EGCG against serial passage-induced senescence were investigated in primary cells including rat vascula...

We present a multilayer study of the Facebook Messages stack, which is based on HBase and HDFS. We collect and analyze HDFS traces to identify potential improvements, which we then evaluate via simulation. Messages represents a new HDFS workload: whereas HDFS was built to store very large files and receive mostlysequential I/O, 90% of files are smaller than 15MB and I/O is highly random. We fin...

IFN-inducible IFI16 protein (encoded by IFI16 gene at 1q23.1) is the human member of the IFN-inducible structurally related p200 family proteins. Increased expression of the IFI16 protein, a positive modulator of p53-mediated transcription, in normal old human diploid fibroblasts (HDF) is associated with cellular senescence-mediated cell growth arrest. However, the underlying mechanisms that co...

The 44-amino acid bovine papillomavirus E5 protein induces tumorigenic transformation of immortal rodent fibroblasts by binding to and activating the platelet-derived growth factor beta receptor (PDGFbetaR). Here E5 was expressed in mortal human diploid fibroblasts (HDFs), which lack the accumulated genetic changes that are present in immortal rodent cells. E5 induced focus formation and morpho...

Objective. This study was aimed at analyzing the expressions of long noncoding RNAs (lncRNAs) in Botulinum Toxin Type A (BoNTA) treated human dermal fibroblasts (HDFs) in vitro. Methods. We used RNA sequencing to characterize the lncRNAs and mRNAs transcriptome in the control and BoNTA treated group, in conjunction with application of GO (gene ontology) analysis and KEGG (kyoto encyclopedia of ...

A reliable, reproducible, and convenient in vitro platform for drug metabolism determination and toxicity prediction is of tremendous value but still lacking. In the present study, a collection of 24 hepatic transcription factors and nuclear receptors in different combinations were surveyed, and 10 among them were finally selected to induce the expression and enzyme activities of cytochrome P45...