We present simulation results on the self-assembly behavior of sickle hemoglobin (HbS). A coarse-grained HbS model, which contains hydrophilic and hydrophobic particles explicitly, is constructed to match the structural properties and physical description of HbS. The hydrophobic interactions are shown to be necessary with chirality being the main driver for the formation of HbS fibers. In the a...

Hbs are widely distributed in higher plants, and by comparing sequences, expression patterns, and ligand-binding properties, it is evident that these fall into two broad groups (Fig. 1; also see Andersson et al., 1996). The symbiotic-type Hbs are predominantly found in the infected cells of nitrogen-fixing nodules of legumes and nonlegumes and function to facilitate oxygen transport. The other ...

The sickle cell (HbS) gene occurs at a variable frequency in the Middle Eastern Arab countries, with characteristic distribution patterns and representing an overall picture of blood genetic disorders in the region. The origin of the gene has been debated, but studies using β-globin gene haplotypes have ascertained that there were multiple origins for HbS. In some regions the HbS gene is common...

Graphene oxide (GO) was functionalized and reduced simultaneously by a new reductant, 4-hydrazinobenzenesulfonic acid (HBS), with a one-step and environmentally friendly process. The hydrophilic sulfonic acid group in HBS was grafted onto the surface of GO through a covalent bond. The successful preparation of HBS reduced GO (HBS-rGO) was testified by scanning electron microscope (SEM), X-ray d...

Supratentorial hemangioblastomas (HBs) are rare, and pituitary stalk HBs are extremely uncommon; therefore, pituitary stalk evaluation is often overlooked. Herein, we report the development of pituitary stalk HB over a 20-year period and the importance of regular long-term follow up for patients with HBs.

A homologous class of histonelike proteins which are believed to wrap the DNA and to condense the chromosome into highly folded nucleoid structures has been identified in different bacterial species. Bacillus subtilis encodes a homodimeric DNA-binding protein called HBsu. We have cloned the corresponding gene (hbs) on a 3.8-kb fragment. The gene was subcloned to a 1-kb fragment, sequenced, and ...

Cell free hemoglobin (Hb), becomes oxidized in the circulation during hemolytic episodes in sickle cell disease (SCD) or thalassemia and may potentially cause major complications that are damaging to the vascular system. Hemolytic anemias are commonly associated with pulmonary hypertension (PH) and often result from dysfunction of lung endothelial cells. The aim of this study was to determine t...

BACKGROUND Health care workers (HCWs) are frequently exposed to hepatitis B virus (HBV) infection. The efficacy and safety of immunization with the hepatitis B (HB) vaccine are well recognized, but the durability of immunity and need for booster doses in those with secondary vaccine response failure remains controversial. METHODS This was a retrospective cohort study performed at Osaka Univer...

OBJECTIVE To determine risk factors associated with hemorrhagic bowel syndrome (HBS) among dairy cattle in the United States and identify characteristics of HBS in individual cows. DESIGN Cross-sectional, population-based survey. SAMPLE POPULATION A stratified random sample of 1,013 dairy operations with > or = 30 cows located in 21 states. PROCEDURE Information on management and animal h...

27 Available data suggest that snake hemoglobins (Hbs) are characterized by a combination of unusual 28 structural and functional properties relative to the Hbs of other amniote vertebrates, including 29 oxygenation-linked tetramer-dimer dissociation. However, standardized comparative data are lacking for 30 snake Hbs, and the Hb isoform composition of snake red blood cells has not been systema...