OBJECTIVE To characterize alpha-chain variant hemoglobins with electric mobility similar to that of hemoglobin S in a newborn screening program. METHODS β(S) allele and alpha-thalassemia deletions were investigated in 14 children who had undefined hemoglobin at birth and an electrophoretic profile similar to that of hemoglobin S when they were six months old. Gene sequencing and restriction e...

OBJECTIVE We studied the influence of positive family history (FH) of type 2 diabetes mellitus (T2DM) in male offspring using multiple metabolic and endocrine parameters in order to assess whether one or more of these parameters can be used as indicators for T2DM development later in life. DESIGN Fifty male subjects with one diabetic parent (ODP) and thirty with both diabetic parents (BDP) we...

Twenty-seven patients with successful transplantation and a control group of 14 patients with early rejection of the pancreas graft but functioning kidney graft were examined in a prospective study for 3 yr. Before transplantation, all patients had long-standing type I diabetes with advanced secondary complications, including end-stage diabetic nephropathy. After transplantation in the patients...

Introduction Elevated HbA2 (hemoglobin A2) level is considered the most reliable hematological parameter for the detection of β-thalassemia carriers. However, some carriers are difficult to recognize because the level of HbA2 is not in the distinctive carrier range, i.e. 4.0-6.0%; instead, some carriers have HbA2 levels between normal and carrier levels, i.e. borderline HbA2 (HbA2 = 3.1-3.9%). ...

OBJECTIVE Since antiquity bitter melon has been in use for treating diabetes but clinical trials show conflicting results about its usefulness. The present study aims to asses and compare the hypoglycemic and antiatherogenic effects as well as the safety of two different doses of bitter melon with glibenclamide. METHODS A total of 95 participants were randomized into 3 groups; group I and gro...

To identify novel genetic loci influencing interindividual variation in red blood cell (RBC) traits in African-Americans, we conducted a genome-wide association study (GWAS) in 2315 individuals, divided into discovery (n = 1904) and replication (n = 411) cohorts. The traits included hemoglobin concentration (HGB), hematocrit (HCT), RBC count, mean corpuscular volume (MCV), mean corpuscular hemo...

The clinical application of insulin glargine combined with other drugs in treating type 2 diabetes (T2D) is increasingly popular worldwide. But there are few studies about the effects of glargine on function of β-pancreatic cells. Thus we aimed to investigate the efficacy of glargine combined with Saxagliptin on treating newly diagnosed type 2 diabetes and their effects on β-cell function. 120 ...

Introduction: Exercise and the use of herbal supplements are among therapeutic interventions in controlling type 2 diabetes. This study aimed to compare effect exercise karela supplement on glycemic control metabolic complications patients with Methods: In present quasi-experimental study, 120 diabetes were selected by purposive sampling randomly divided into 4 groups exercise, supplement, comb...

We compared results for glycohemoglobin obtained from fresh whole blood or separated erythrocyte samples with results obtained after storage. We judged the storage condition to be acceptable ("stable") if the glycohemoglobin results after storage were within the 95 confidence interval (+/- SD) of the results obtained for the specimens on the day of venipuncture. Hemolysates can validly be store...