UNLABELLED The HIV-1 envelope glycoprotein (Env) is a trimer of gp120-gp41 heterodimers and is essential for viral entry. The gp41 subunit in native, prefusion trimeric Env exists in a metastable conformation and attains a stable six-helix bundle (6-HB) conformation comprised of a trimer of N-heptad repeat (NHR) and C-heptad repeat (CHR) heterodimers, that drives the fusion of viral and cellula...

Potential of Family Health Strategy Against Cardiovascular Disease Gilberto Andrade Tavares1 and José Augusto Soares Barreto-Filho2,3,4 Núcleo de Pós-Graduação em Ciências da Saúde da Universidade Federal de Sergipe (UFS),1 São Cristóvão, SE; Núcleo de Pós-Graduação em Medicina Universidade Federal de Sergipe;2 Divisão de Cardiologia Hospital Universitário;3 Clínica e Hospital São Lucas,4 Araca...

BACKGROUND Health care workers (HCWs) are frequently exposed to hepatitis B virus (HBV) infection. The efficacy and safety of immunization with the hepatitis B (HB) vaccine are well recognized, but the durability of immunity and need for booster doses in those with secondary vaccine response failure remains controversial. METHODS This was a retrospective cohort study performed at Osaka Univer...

OBJECTIVE To evaluate the safety and immunogenicity of an indigenous hepatitis B, diphtheria, tetanus and B. pertussis tetravalent vaccine (Shantetra) in comparison with Tritanrix HBTM in healthy Indian infants. DESIGN Multicentric, randomized, single blind intention-to-treat study with 12-18 weeks of follow up period. SETTING 5 out patient departments at tertiary care referral centers acro...

1. Diez-Delgado J, Dal-Ré R, Llorente M, González A, López J. Hepatitis B component does not interfere with the immune response to diphtheria, tetanus and whole-cell Bordetella pertussis components of a quadrivalent (DTPw-HB) vaccine: a controlled trial in healthy infants. Vaccine1997; 15: 1418-1422. 2. Shah R, Raghu MB, Shivanada A, Mangayarkarasi S, Rao I, Rao R, et al. Immunogenicity and saf...

background: 1.3% of people in iran are positive for anti-hbc antibody.the objective of this study is to determine the rate of seroconversion in those with persistent isolated anti-hbc after vaccination. materials and methods: in a quasi-experimental study, 94 persons with isolated anti-hbc antibody who were referred to tehran blood transfusion organization between 2002 and 2004 were selected th...

background: hepatitis b virus is one of the most common causes of chronic liver diseases. vaccination is the best way of prophylaxis and is of utmost importance. this study was conducted to compare the prophylactic effect of intradermal and intramuscular injection of hepatitis b vaccine. methods: a blind randomized clinical trial was performed among subjects who presented to the infectious dise...

The aim was to study the association of CD150 expression in peripheral blood mononuclear cells (PBMCs) with response to hepatitis B (HB) vaccination. Heparinized blood drawn from non-responders and responders was used to obtain PBMCs. Out of 460 adult healthy males and non-pregnant females, 27 subjects who were negative for HB markers were defined as non-responders (15 males and 12 females, age...

context hepatitis b virus expanded program on immunization (epi) started on 1993 in iran. most surveys have assessed the level of response to vaccine by measuring the titers of anti-hbs. this meta- analysis aimed to summarize the iranian published data on the rate of vaccine-responders versus non-responders. moreover, the impact of variables such as age, gender, type of vaccine, etc. on the lev...