Exercise regimens may have differing effects in the presence of obesity. In addition to being fat derived, adiponectin has recently been described as a myokine that regulates insulin sensitivity, which may link to exercise-related metabolic benefits in obesity. Whether skeletal muscle adiponectin varies in different exercise modalities is unclear. This study investigated the comparative effects...

Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are characterized by early suppression of the host innate immune system. One of the proteins likely responsible for this effect is VP24. VP24 is known to antagonize interferon signaling by binding host karyopherin α proteins, thereby preventing them from transporting the tyrosine-phosphorylated transcription facto...

OBJECTIVE/HYPOTHESIS To determine the clinical yield of neck and chest computed tomography in the initial assessment of patients with idiopathic unilateral true vocal fold paresis. STUDY DESIGN Retrospective chart review. METHODS A retrospective chart review of consecutive adult patients with idiopathic unilateral true vocal fold paresis diagnosed by stroboscopy in a tertiary-care voice cen...

Two RNases, Dicer and Argonaute, are at the heart of the RNA interference (RNAi) molecular machinery responsible for gene silencing. Both RNases contain multiple domains, most of which have been characterized or have functions that can be predicted based on sequence comparisons. However, Dicers of higher eukaryotes contain the domain known as DUF283 which at present has no assigned role. Using ...

Nuclear factors NF90 and NF45 form a complex involved in a variety of cellular processes and are thought to affect gene expression both at the transcriptional and translational level. In addition, this complex affects the replication of several viruses through direct interactions with viral RNA. NF90 and NF45 dimerize through their common 'DZF' domain (domain associated with zinc fingers). NF90...

The ligand binding domain of glutamate receptors (GluRs) has 2-fold rotational symmetry. The structure including the symmetry of the GluR ion channel remains undefined. Here we used substituted cysteines in the pore-lining M3 segment of the AMPAR GluR-A subunit and various cysteine-reactive agents to study the structure of the channel during gating. We find that cysteines substituted at A+6, lo...

uncertainty associated with mixing models is often substantial, but has not yet been fully incorporated in models. the objective of this study is to develop and apply a bayesian-mixing model that estimates probability distributions of source contributions to a mixture associated with multiple sources for assessing the uncertainty estimation in sediment fingerprinting in zidasht catchment, iran....

history has repeatedly acknowledged the contributions of iranian scientist to man kind. in recent years the courageous integration of medical education with health unique in its characteristic and dimension had reshaped the face of iran's medical as any other change there has been short comings but the potentials created is promising. the article gives a brief history of science and specially m...