نتایج جستجو برای: harmine

تعداد نتایج: 271  

Journal: :Archives of pharmacal research 2009
Xi-yuan Zheng Zi-jia Zhang Gui-xin Chou Tao Wu Xue-mei Cheng Chang-hong Wang Zheng-tao Wang

Acetylcholinesterase inhibitors (AChEIs) currently form the basis of the newest drugs available for the treatment of Alzheimer's disease. For the aim of screening effective AChEIs, the methanol extracts of the seeds of genus Peganum were found to show significant inhibitory activity of acetylcholinesterase enzyme (AChE) using an in vitro TLC-bioautographic assay. In further studies to seed of P...

Journal: :Physical chemistry chemical physics : PCCP 2015
Dalibor Hršak Lotte Holmegaard Anton S Poulsen Nanna H List Jacob Kongsted M Paula Denofrio Rosa Erra-Balsells Franco M Cabrerizo Ove Christiansen Peter R Ogilby

A combined experimental and computational study of solvent effects on one- and two-photon absorption spectra of three chlorinated harmine derivatives is presented. The systems studied were protonated forms of 6-chloroharmine, 8-chloroharmine and 6,8-dichloroharmine in two solvents, acetonitrile and water. For the computations, polarizable embedding density functional and coupled cluster respons...

Journal: :Biomedicina 2021

A derivative of the beta-carboline alkaloid harmine — drug hydrochloride was studied for presence antihypoxic properties in models hypobaric hypoxia and normobaric with hypercapnia. It found that does not have a signifi cant compensatory effect test At same time, small doses (2.5 5 mg/kg) has activity test, which is expressed statistically increase life expectancy animals treated drug, compared...

Journal: :iranian journal of biotechnology 2014
sahar seyed hassan tehrani somayeh hashemi sheikh shabani sattar tahmasebi enferadi zohreh rabiei

background: ß-carbolines, harmaline and harmine, are the major alkaloids presenting in the seeds of the peganum harmala l. these alkaloids are known as herbal active principals with potential use in pharmaceutical and medicine. objectives: to assess the growth inhibitory effect of phyto-alkaloids, harmaline and harmine, on cancer cell lines. methods: the p. harmala l.’s alkaloids were extracted...

2011
Danielle Frost Bessie Meechoovet Tong Wang Stephen Gately Marco Giorgetti Irina Shcherbakova Travis Dunckley

Harmine, a β-carboline alkaloid, is a high affinity inhibitor of the dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) protein. The DYRK1A gene is located within the Down Syndrome Critical Region (DSCR) on chromosome 21. We and others have implicated DYRK1A in the phosphorylation of tau protein on multiple sites associated with tau pathology in Down Syndrome and in Alzheime...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید