This paper considers the random simulation of genotypes from relative pairs using R. After Hardy-Weinberg equilibrium law is introduced systematically, joint probability distributions general are studie. Then ITO method was discussed in detail. Based on theo ry described above, computer program for written According to these R codes, can be easily generated randomly.

Genotype polymorphism studies at nine short tandem repeat (STR) loci (D3S1358, FGA, TH01, D7S820, VWA, CSF1PO, D5S818, D13S317, TPOX) were carried out in two Ethnic Groups (Tu, Sala) living in Qinhai, a North-West province of China. All loci were in accordance with Hardy-Weinberg equilibrium (P = 0.05).

I show that fine-scale localization of a survival-related locus can be accomplished on the basis of deviations from Hardy-Weinberg equilibrium and linkage disequilibrium at closely linked marker loci. The method is based on chi(2)-tests and they can be performed for age-specific samples of alive (or dead) individuals, as for combined samples of alive and dead individuals.