The chromatin-remodelling complex SNF2-related CBP activator protein (SRCAP) regulates chromatin structure in yeast by modulating the exchange of histone H2A for the H2A.Z variant. Here, we have investigated the contribution of H2A.Z-mediated chromatin remodelling to mammalian cell differentiation reprogramming. We show that the SRCAP subunit named ZNHIT1 or p18(Hamlet), which is a substrate of...

Inductive Logic Programming (ilp) methods have proven to succesfully acquire knowledge in very different learning paradigms, such as supervised and unsupervised learning or relational reinforcement learning. However, very little has been done on General Problem Solving (gps). One of the ilp-based approaches applied to gps is hamlet. This method is able to learn control rules (heuristics) for a ...