OBJECTIVES To determine whether second-generation-antipsychotics (SGAs) are effective for negative symptoms treatment in schizophrenia. METHODS Two meta-analyses were carried out using placebo or haloperidol as comparators. The search included the following databases: Pubmed, The Cochrane Central Register of Controlled Trials, Proquest Health and Medical Complete, Science Citation Index Expan...

Introduction: Adjuvant medications can be used to increase the analgesic effect of opioid analgesics, reduce manifestation side effects, and also for premedication. This paper provides information on clonidine, haloperidol, metocloparmide, diazepam, midazolam analgesics: - morphine selective kappa-opioid agonist compound RU-1205.
 Materials methods: A probable interaction between RU-1205, ...

The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. haloperidol, reduce the positive symptoms of schizophrenia, but have no effect in treating the negative symptoms of the disease. In addition, prolonged use of these drugs often...

Abstract Objectives The duration of administration (e.g., subchronic or chronic) haloperidol may influence its adverse effects. We studied the effects on body weight and fasting blood sugar (FBS). In addition, we examined whether orally administered cannabidiol (CBD) had any putative mitigating haloperidol-induced changes FBS elevation. Methods Haloperidol (5 mg/kg/day) was for 21 days (subchro...

This randomized within-subject, double blind study aimed to compare the effects of a single dose of two different antipsychotics (haloperidol and aripiprazole) on cortisol, interleukin (IL)-6 and hippocampal regional Cerebral Blood Flow (rCBF) in the same 17 healthy male individuals. Subjects received a single dose of haloperidol (3mg), aripiprazole (10mg) and placebo, in a randomized order on ...

A single dose of typical neuroleptic, haloperidol, has been demonstrated to increase the expression of neurotensin/neuromedin N (NT/N) mRNA in the dorsolateral striatum within 1 hr of its administration (Merchant et al., 1991). The present study further investigated neuroleptic-induced regulation of NT/N gene transcription. Levels of NT/N mRNA were examined at various times following a single d...

OBJECTIVE To compare the effect of intramuscular olanzapine with intramuscular haloperidol plus promethazine on rapid tranquillisation of agitated or violent people with mental illness. DESIGN Pragmatic, allocation concealed, randomised controlled trial. SETTING Emergency services of a general hospital psychiatry department in Vellore, south India. PARTICIPANTS 300 adults with agitated or...

The existence of multiple receptor sites for the psychotomimetic agents phencyclidine (PCP) and some opiate-benzomorphans such as (+)N-allylnormetazocine ([+]SKF 10,047) in the mammalian central nervous system is well documented. These are: 1) sigma/PCP (sigma p) site, which binds both PCP and psychotomimetic opiates but not antipsychotics such as haloperidol, 2) PCP site, which selectively bin...