Red algae of Laurencia continue to provide wide structural diversity and complexity of halogenated C15 acetogenin medium-ring ethers. Here, we described the isolation of three new C15 acetogenins (3-5), and one truncated derivative (6) from Laurencia viridis collected on the Canary Islands. These compounds are interesting variations on the pinnatifidenyne structure that included the first examp...

Gas chromatography-mass spectrometry (GC-MS) was used to detect 2-docosanol, a secondary alcohol characteristic of Mycobacterium xenopi, in 7 of 10 analyzed drinking water samples culture positive for that species. GC-MS was also used to detect tuberculostearic acid. Both of these chemical markers were analyzed as halogenated derivatives in the negative-ion-chemical-ionization mode. The numbers...

Potential synthesis of a series of 3-amino-4arylazothiophene derivatives from reaction of 2-cyano-2phenylthiocarbamoyl acetamide and the appropriate α-halogenated reagents, followed by coupling with different aryl diazonium salts (Japp-Klingemann reaction), and another series of 5-arylazo-thiazol2-ylcarbamoyl-thiophene derivatives from base-catalyzed intramolecular condensation of 5-arylazo-2-(...

Benzimidazole, which is a heterocyclic nucleus, plays an important role in various medicines. A number of therapeutic agents such as H1 antihistaminic agent clemizole, a potent opioid analgesic etonitazene, nonnucleoside antiviral compound enviroxime, for promotion of excretion of uric acid irtemazole, non sedating antihistaminic agent astemizole, anti ulcer drugs omeprazole and pentoprazole, a...

conclusions hepatotoxicity of halogenated inhalational anesthetics has been well documented in available literature. halothane-induced liver injury was extensively acknowledged; however, the next generation halogenated anesthetics have different molecular structures and associated with less hepatotoxicity. although anesthesia-induced hepatitis is not a common occurrence, we must consider the as...

a counterion for the isolation of reactive cations, and for activation of catalysts in organic synthesis. Its unique electronic and molecular structures render 1 as an attractive starting material for the construction of various functional molecules and bioactive/pharmaceutical building blocks. However, progress in the synthesis of such materials is hindered by the lack of methods for the funct...

Fluorine has been shown in many cases to impart specific and predictable effects on molecular conformation. Here it is shown that these conformational effects may have an influence on reactivity through studying the relative reactivity of various α-halogenated ketones towards borohydride reduction. These results demonstrate that the α-fluoro ketones are in fact a little less reactive than the c...

A rhodium-catalysed stitching reaction between 2-(silylethynyl)arylboronates and 2-(silylethynyl)aryl bromides has been developed for the synthesis of unsymmetric dibenzo[a,e]pentalenes. The introduction of appropriately sized silyl groups on the starting substrates led to a high crossover selectivity without using an excess amount of either substrate. The present stitching reaction could produ...

conclusions despite the adverse effects of inhalational halogenated anesthetics (especially halothane) on hepatic patients when necessary. the effects on all systems must be considered and the necessary preparations must be provided. these drugs are still used, if necessary, due to the presence of positive effects and advantages mentioned in other studies as well as the adverse effects of other...

Efficiencies of organic solar cells have practically doubled since the development non-fullerene acceptors (NFAs). However, generic chemical design rules for donor-NFA combinations are still needed. Such proposed by analyzing inhomogeneous electrostatic fields at donor–acceptor interface. It is shown that an acceptor–donor–acceptor molecular architecture, and alignment parallel to interface, re...