Pulmonary toxicity with mefloquine. E. Udry, F. Bailly, M. Dusmet, P. Schnyder, R. Lemoine, J.W. Fitting. #ERS Journals Ltd 2001. ABSTRACT: This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy. Extensive microbiological investigation remained ne...

A second haemolytic crisis of blackwater fever (BWF) following a combination of artemether-lumefantrine intake, in an 8-year-old Congolese boy is reported. The patient had a history of BWF after quinine intake. He was given artemether-lumefantrine treatment for malaria. He was free from G6PD deficiency and abnormal haemoglobin. Sepsis was eliminated. Haemolysis was noted with 5.6 g/dl of haemog...

2 4. Kirby GC, Paine A, Warhurst DC, Noamesi BK, Phillipson JD. In vitro and in vivo antimalarial activity of cryptolepine, a plant-derived indoloquinoline. Phytother Res 1995; 9: 359-363 5. Noamesi BK, Paine A, Kirby GC, Warhurst DC, Phillipson JD. In vitro antimalarial activity of cryptolepine, an indoquinoline. Trans Roy Soc Trop Med Hyg 1991; 85:315 6. Boye GL. Studies on antimalarial actio...

Discussion Although multiresistant P. faldipamm is an increasing problem, reports of P . vivax resistant to chloroquine have been few. The above case reports document the presence of chloroquine-resistant P. vivax in India, and show that it may not be as rare as it i s presumed to be. Also, the number of drug resistant strains is probably increasing. Antimalarial drugs other than chloroquine us...