The regiocontrolled preparation of triarylisothiazoles is presented. 3-Halo-5-phenylisothiazole-4-carbonitriles, 1 (hal=Cl) and 18 (hal=I), are converted into the corresponding 4-bromo derivatives 5 (3-hal=Cl) and 24 (3-hal=I) via a Hunsdiecker strategy while the 4-iodo analogues 7 (3-hal=Cl) and 22 (3-hal=I) are prepared via a Hoffmann and Sandmeyer strategy. Regioselective Suzuki, Stille and ...

Nach dem kurzen Bericht ueber die Geschichte van Tetanus; haben wir in diesern Artikel ver­sucht,ueber die Epedirniologie, Pathophisiolo­gie,Aethiologie und die Frueh-und Spaet-Symp­ptome von dieser gcfahrlichen Krankheit,die einen Durchschnitt von 35% Mortalitaet hat,zu berichten.  In disern Artikel legen wir vi.ei wert,besoaders ueber die The·.rapie 1md der Prophyla.xe. Unc:I wii' hal)en bed...

Trials of novel compounds for the treatment of schizophrenia are typically tested in patients following brief withdrawal of ongoing medication despite known long-term changes in the dopamine (DA) system following chronic antipsychotic drug therapy. The present study explored the impact of withdrawal from repeated haloperidol (HAL) treatment, as well as the response to a novel α5 gamma-aminobuty...

'Hong Anliu' (HAL, Citrus sinensis cv. Hong Anliu) is a bud mutant of 'Anliu' (AL), characterized by a comprehensive metabolite alteration, such as lower accumulation of citrate, high accumulation of lycopene and soluble sugars in fruit juice sacs. Due to carboxylic acid metabolism connects other metabolite biosynthesis and/or catabolism networks, we therefore focused analyzing citrate accumula...

The hybrid assistive limb (HAL) exoskeleton provides rehabilitation of the motor skills of chronic spinal chord injury (SCI) patients as well as alleviation of chronic neuropathic pain (CNP). The HAL device uses bioelectric signals to activate robotic support of voluntary movement during bodyweight supported treadmill training (BWSTT).

The HAL language includes a Herbrand constraint solver which uses Taylor’s PARMA scheme rather than the standard WAM representation. This allows HAL to generate more efficient Mercury code. Unfortunately, PARMA’s variable representation requires value trailing with a trail stack consumption about twice as large as for the WAM. We present a trailing analysis aimed at determining which Herbrand v...

This study evaluated the inter-rater reliability of the American Conference of Governmental Industrial Hygienists (ACGIH®) hand activity level (HAL), an observational ergonomic assessment method used to estimate physical exposure to repetitive exertions during task performance. Video recordings of 858 cyclic and non-cyclic appliance manufacturing tasks were assessed by sixteen pairs of raters u...