Patients with a variety of haematological conditions are at risk of infection and its most serious complication: septic shock. Mortality for septic shock remains high and especially so in patients with haematological malignancy and following bone marrow transplantation. However, advances in the treatment of severe sepsis have improved mortality rates even though evidence for the management of s...

The problem of novel FVIII missense mutations for haemophilia A genetic counseling R. Schneppenheim1; J. Schröder2; T. Obser1; F. Oyen1; S. Schneppenheim3; J. Oldenburg2 1Department of Paediatric Haematology & Oncology, University Medical Center Hamburg-Eppendorf, Germany; 2Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Germany; 3Coagulation Laboratory A...

Haematology Oncology Group, Cancer Sciences Unit, Cancer Research UK Centre and National Institute for Health Research Experimental Cancer Medicine Centre, University of Southampton, Faculty of Medicine, Southampton, United Kingdom; Haematology Department, University Hospital Southampton National Health Service Trust, Southampton, United Kingdom; and School of Cancer Sciences, University of Bir...

Department of Pediatric Hemato-Oncology, Edmond and Lily Safra Children’s Hospital, Sheba Medical Centre, Tel-Hashomer, Ramat Gan, and Tel Aviv University Medical School, Tel Aviv, Israel; Department of Haematology, Sheffield Children’s Hospital, Sheffield, United Kingdom; Pediatric Oncology/ Hematology, Erasmus MC–Sophia Children’s Hospital, Rotterdam, The Netherlands; and Division of Haematol...

Midori Shima, Jecko Thachil, Sukesh C Nair, Alok Srivastava Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan,Department of Haematology, Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, Liverpool, UK, Department of Transfusion Medicine and Immunohaematology, Christian Medical College, Vellore, India, Department of Haematology at Christia...

Department of Paediatrics, Paediatric Intensive Care Unit, Hospital Santa Maria, Lisbon Academic Medical Centre, Lisboa, Portugal Department of Paediatrics, Centro Hospitalar BarreiroMontijo, Barreiro, Portugal Clinical Haematology Service, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal Department of Paediatrics, Haematology Unit, Hospital Santa Maria, Lisbon Academic Medical Cen...

1Clinical Trial Service Unit and 2Cancer Epidemiology Unit, University of Oxford, Oxford; 3Haemophilia Centre, Churchill Hospital, Oxford; 4Department of Haematology, Birmingham Children’s Hospital National Health Service Trust, Birmingham; 5Department of Haematology, Manchester Royal Infirmary, Manchester; 6Haemophilia Centre, Royal Free Hospital, London; 7Haemophilia Centre, Edinburgh Royal I...

1Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; 2Department of Haematology, The Alfred Hospital, Melbourne, Australia; 3Diagnostic Haematology, Melbourne Health, Royal Melbourne Hospital, Melbourne, Australia; 4Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; and 5Biomedi...