Hydrogen peroxide causes vascular contraction and relaxation and contributes to the pathogenesis of hypertension. We hypothesized that the contractile state of blood vessels governs whether H2O2 causes contraction or relaxation. Hydrogen peroxide (1 micromol/L to 1 mmol/L) concentration-dependently contracted thoracic aorta and vena cava from sham normotensive and deoxycorticosterone acetate (D...

The objective of this study was to compare the efficiency of O3/granular activated carbon (GAC) to enhance ozone transformation into OH radicals, with the common advanced oxidation processes (O3/OH , O3/H2O2). The results obtained with model systems under the given experimental conditions showed that the system O3/OH (pH 9) and O3/H2O2 (pH 7, [H2O2] = 1 10 -5 M) are more efficient than O3/GAC (...

Cancer cells may be more prone to the accumulation of reactive oxygen species (ROS) than normal cells; therefore increased oxidative stress can specifically kill cancer cells including cancer stem cells (CSCs). In order to generate oxidative stress in various cancer cell lines including A549, G361 and MCF-7, cultured cells were exposed to H2O2. Incubation of cancer cells with H2O2 results in co...

19 Fe/ascorbate, hydrogen peroxide (H2O2) and hypoxanthine/xanthine oxidase (XOD) are commonly used for 20 inducing oxidative stress on spermatozoa. A comparative study of these agents was carried out on thawed 21 spermatozoa from red deer. First, we tested a high, medium and low concentration of each agent: 100, 10 and 22 1 μM Fe (hydroxil radical generator); 1 mM, 100 and 10 μM H2O2; and 100,...

OBJECTIVE Echium amoenum Fisch. & C.A. Mey. is used for the treatment of various diseases in traditional medicine. This plant is a major source of anthocyanins with beneficial cardiovascular properties such as anti-atherosclerotic and antihypertensive effects. In the present study, the protective and antioxidant effects of anthocyanin-rich E. amoenum extract were evaluated on human vascular end...

background: recently, there has been a great concern about the consumption of dyes because of their toxicity, mutagenicity, carcinogenicity, and persistence in the aquatic environment. reactive dyes are widely used in textile industry. advanced oxidation processes are one of the cost-effective methods for the removal of these dyes. the main aims of this study were determining the feasibility of...

The capability of Cr(III) to induce DNA lesions generated by oxidative damage was investigated in this study by examining the formation of 8-hydroxydeoxyguanosine (8-OHdG) in calf thymus DNA by CrCl3 and/or H2O2 in 10 mM phosphate buffer. In the presence of 0.5 mM H2O2, the formation of 8-OHdG markedly increased with increasing CrCl3 concentration. In contrast, H2O2 or CrCl3 alone did not cause...

Stimulated inflammatory cells release large amounts of hydrogen peroxide (H2O2). Breath condensate H2O2 has been shown to be elevated in stable asthmatic children, chronic obstructive pulmonary disease and intubated adult respiratory distress syndrome. In cystic fibrosis airways, where neutrophilic inflammation dominates, it is postulated that H2O2 in breath condensate would be elevated and may...