The cystathionine ß-synthase (CBS) is a critical enzyme in the transsulfuration pathway and is responsible for the synthesis of cystathionine from serine and homocysteine. Cystathionine is a precursor to amino acid cysteine. CBS is also responsible for generation of hydrogen sulfide (H2S) from cysteine. Mutation in CBS enzyme causes homocysteine levels to rise, and gives rise to a condition cal...

Over the last decade, hydrogen sulfide (H2S) has emerged as an important endogenous gasotransmitter in mammalian cells and tissues. Similar to the previously characterized gasotransmitters nitric oxide and carbon monoxide, H2S is produced by various enzymatic reactions and regulates a host of physiologic and pathophysiological processes in various cells and tissues. H2S levels are decreased in ...

Hydrogen sulfide (H2S), is a relevant mediator in cardiovascular physiology. Indeed, impaired production of H2S contributes to the pathogenesis of important cardiovascular disorders [1]. Accordingly, exogenous compounds, acting as H2S-releasing agents, are viewed as promising therapeutic agents for cardiovascular diseases. Thus, this work aimed at evaluating the H2S-releasing properties of the ...

Hydrogen sulfide (H2S) is enzymatically generated in mammalian tissues from either L-cysteine or L-homocysteine. H2S possesses multiple biological activities, including regulation of vascular tone and blood pressure. Hydrogen sulfide produced in endothelial cells, vascular smooth muscle cells, and perivascular adipose tissue dilates blood vessels by activating ATP-sensitive potassium channels. ...

•Type B cells are ultrasensitive H2S detectors that integrate distinct danger inputs•Cnga2 and Trpc2 operate in separate subcellular compartments of the same cell•Cnga2 but not is required for detection by type cells•H2S drives stress hormone release, self-grooming, place avoidance The olfactory system serves a critical function as to trigger defense responses essential survival. cellular molec...