Multiple Sequence Alignment (MSA) is a fundamental tool of bioinformatics. Row-Column MSA (RC-MSA) methods such as CLUSTALW [12] produce tabular alignments that are now familiar. However, these methods have a number of shortcomings, including difficulty of understanding the result, high computational complexity, questionable assumptions, and other artifacts (such as poor handling of prefixand s...

Cognitive impairment and affective dysfunction of multiple system atrophy (MSA) and cortical cerebellar atrophy (CCA) have not been simultaneously examined comparing standard test batteries and a sensitive tool to detect subtle cognitive decline in patients. In the present study, we simultaneously examined cognitive and affective ability in MSA with predominant cerebellar ataxia (MSA-C, n=25), ...

The reasons for the differences in emphasis on striatonigral or olivopontocerebellar involvement in multiple system atrophy (MSA) remain to be determined. Semi-quantitative pathological analyses carried out in the United Kingdom and Japan demonstrated that olivopontocerebellar-predominant pathology was more frequent in Japanese MSA than British MSA. This observation provides evidence for a diff...

this paper presents an efficient mechanism to convert sana’ani dialect to modern standard arabic. the mechanism is based on morphological rules related to sana’ani dialect as well as modern standard arabic. such rules facilitate the dialect conversion to its corresponding msa. the mechanism tokenizes the input dialect text and divides each token into stem and its affixes; such affixes can be ca...

BACKGROUND Vascular endothelial growth factor (VEGF) currently is being evaluated in clinical angiogenesis trials involving patients with peripheral arterial disease. We hypothesized that delivery of VEGF to the skeletal muscle of the lower extremity using an adenoviral vector (Ad(GV)VEGF(121.10)) would improve peripheral endothelial function. Accordingly, we investigated lower-extremity endoth...

Due to scarce available experimental data, as well as due to the absence of predictive models, the influence of salts on the solubility of ionic liquids (ILs) in water is still poorly understood. To this end, this work addresses the solubility of the IL 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([C4C1im][NTf2]), at 298.15 K and 0.1 MPa, in aqueous salt solutions (from 0.1 to...

BACKGROUND Both homeless women and women who have experienced military sexual assault (MSA) are at high risk of serious psychological sequelae. However, little is known about the combined impact of MSA and current homelessness on psychological distress, or about distinctive treatment preferences among homeless female veterans affected by MSA. METHODS This observational study compared clinical...

This paper utilizes global variance (GV) of the log power spectrum (LPS) derived from mel-cepstrum to improve hidden Markov model (HMM) based parametric speech synthesis. In order to alleviate over-smoothing of the generated spectral structures, an LPS-GV modeling method using line spectral pairs (LSPs) has been proposed in our previous work, where the estimated distribution of LPS-GV was combi...

BACKGROUND We assessed the maturational competence and the chromosomal pattern of mouse oocytes reconstructed by germinal vesicle (GV) transfer technique using nuclear and/or cytoplasmic components from cryopreserved GV stage oocytes. METHODS From 657 GV oocytes (326 fresh and 331 frozen/thawed), four groups of reconstructed oocytes were obtained by micromanipulation and electrofusion: fresh ...