Synthetic chemists have provided a wide array of supramolecular assemblies able to encapsulate guest molecules. The scope of this tutorial review focuses on supramolecular host molecules capable of reversibly encapsulating polyatomic guests. Much work has been done to determine the mechanism of guest encapsulation and guest release. This review covers common methods of monitoring and characteri...

Here we describe the inclusion of minor-groove binding drug pentamidine in its extended conformation into macrocyclic cavity water-soluble carboxylated pillar[5]arene. The artificial host–guest system is manifested as an ensemble three crystalline forms differing pillar[5]arene–pentamidine interaction mode, solvation type, and even stoichiometry. strong hydrogen bonds various types amidinium–ca...

CO2 capture on solid materials possesses significant advantages on the operation cost, process for large-scale CO2 capture and storage (CCS) that stimulates great interest in exploring high-performance solid CO2 adsorbents. A ship-in-a-bottle strategy was successfully developed to prepare the [APMIM]Br@NaY host-guest system in which an amine-functionalized ionic liquid (IL), 1-aminopropyl-3-met...

Modeling the structure of natively disordered peptides has proved difficult due to the lack of structural information on these peptides. In this work, we use a novel application of the host-guest method, combining folding theory with experiments, to model the structure of natively disordered polyglutamine peptides. Initially, a minimalist molecular model (C(alpha)C(beta)) of CI2 is developed wi...

Two sets of cyan and yellow fluorescent proteins, monomeric analogues, and analogues with a weak affinity for dimerization were functionalized with supramolecular host-guest molecules by expressed protein ligation. The host-guest elements induce selective assembly of the monomeric variants into a supramolecular heterodimer. For the second set of analogues, the supramolecular host-guest system a...

EUDOC is a docking program that has successfully predicted small-molecule-bound protein complexes and identified drug leads from chemical databases. To expand the application of the EUDOC program to supramolecular chemistry, we tested its ability to reproduce crystal structures of small-molecule complexes. Of 161 selected crystal structures of small-molecule guest-host complexes, EUDOC reproduc...

The surface plasmon resonance (SPR) technique has been primarily used in the field of biology, in particular for the study of antibody-antigen interactions. Recently, polymers were introduced to form inclusion complexes. We describe here, a methodology based on surface plasmon resonance imaging to study water-resistant and reversible inclusion complexes using systems which are compatible with a...

As ARM CPUs become increasingly common in the server world, virtualization technologies for mobile systems need to be extended for ARM server systems. However, because this system has the limited resources compared to the traditional x86 server system, new virtualization technologies should be considered to allow as many virtual machines as possible to run efficiently and simultaneously on sing...

A convenient methodology for the synthesis of photolabile crosslinked hyperbranched polyglycerol nanocapsules is presented. These nanocarriers selectively and efficiently bind ionic guest molecules. The stability of the host-guest complexes formed depends on the counterion of the guest molecules. Moreover, the control over guest binding can be achieved by modification of the polymer building bl...

Virtualization is a fundamental component in cloud computing because it provides numerous guest VM transparent services, such as live migration, high availability, rapid checkpoint, etc. Utilizing virtualization technology to combine real-time operating system (RTOS) and off-the-shelf time-sharing general purpose operating system (GPOS) is attracting much more interest recently. Such combinatio...