Background Recently with the improvement of people’s living standards, eating fine, irregular life, lack of exercise and increased mental stress, the incidence of constipation is increasing. Gastrointestinal (GI) tract’s pressure information can reflect the dynamic disorder of gastrointestinal physiological and pathological changes, which is important in early diagnosis and treatment of constip...

OBJECTIVE This study was designed to analyze the results of treatment on patients with metastatic gestational trophoblastic tumor (metastatic GTT). METHOD During 1996-2001, 38 cases with metastatic GTT were diagnosed and received treatment in Vali-e-Asr Hospital, Tehran, Iran. Data were gathered retrospectively and analyzed based on therapy and response rate. Sixteen patients initially labele...

Objective. Wireless capsule endoscopy (WCE) is commonly used to directly visualize the small bowel. Opioids have variably been linked with incomplete studies and prolonged transit times in heterogeneous cohorts. We aimed to investigate the effect of opioid use on WCE for inpatient and outpatient cohorts. Methods. We performed a retrospective review of patients receiving WCE at our institution f...

Dna2 is a nuclease/helicase with proposed roles in DNA replication, double-strand break repair and telomere maintenance. For each role Dna2 is proposed to process DNA substrates with a 50-flap. To date, however, Dna2 has not revealed a preference for binding or cleavage of flaps over single-stranded DNA. Using DNA binding competition assays we found that Dna2 has substrate structure specificity...

Background: Malathion (MT), an organophosphorus pesticide, induces hepatotoxicity and is associated with hyperglycemia and the development of diabetes mellitus.  Objectives: This study was aimed to evaluate the effects of sub-acute exposure to sub-lethal dose of MT in the liver of diabetic rats.  Methods: Non-diabetic and streptozotocin-induced diabetic rats received MT at a dose of 150 mg/kg...

The nematode, Caenorhabdltls e l egans , conta ins a family of s ix genes that code for v i t e l l o g e n l n s . Here we repor t the complete nucleot lde sequence of one of these genes, v i t 5 . The gene spec i f i e s a mRNA of 4869 nuc l eo t ide s , including un t rans la ted regions of 9 bases at the 5 ' end and 51 bases at the 3 ' end. Vit-5 contains four short in t rons t o t a l l i ...

Sickle cell disease is characterized by a structural abnormality in the beta-globin chain of the hemoglobin molecule within the red blood cells (RBCs). The sickle mutation is a single base change (GAT → GTT) in the sixth codon of exon-1 of the betaglobin gene on chromosome 11. This change leads to the synthesis of the beta-globin polypeptide of the hemoglobin molecule. This mutation causes the ...

background polycystic ovary syndrome (pcos) is a common disease in young women that is associated with infertility and other complications such as obesity, hirsutism and insulin resistance and also the disorder that mostly is specified with oligomenorrhoea or amenorrhea with clinical or laboratory evidence of hyperandrogenemia. objectives the purpose of this study was to investigate whether mea...