نتایج جستجو برای: gsh depletion

تعداد نتایج: 71935  

Journal: :Anticancer research 2010
Yong Hwan Han Yeon Mi Yang Sung Zoo Kim Woo Hyun Park

MG132 as a proteasome inhibitor can induce apoptotic cell death through formation of reactive oxygen species (ROS). In this study, the effects of N-acetyl cysteine (NAC; an antioxidant) on MG132-induced HeLa cell death in relation to ROS and glutathione (GSH) were investigated. MG132 induced cell growth inhibition and apoptosis in HeLa cells, which was accompanied by the loss of mitochondrial m...

2000
Nosratola D. Vaziri Xiu Q. Wang Fariba Oveisi Behdad Rad

Several recent studies have shown that certain forms of genetic or acquired hypertension are associated with oxidative stress and that animals with those types of hypertension respond favorably to antioxidant therapy. We hypothesize that oxidative stress may cause hypertension via (among other mechanisms) enhanced oxidation and inactivation of nitric oxide (NO). To test this hypothesis, Sprague...

2006
Roger R. Perry Bridget R. Greaves Uli Rasberry Sam C. Barranco

Glutathione (GSH) has been shown to modulate the Cytotoxicity of a variety of chemotherapeutic agents. The effect of mitomycin C (MMC) treatment duration and the effect of GSH depletion on in vitro cytotoxicity against the human colon cancer cell line 111-29 »asstudied under aerobic conditions. Continuous-exposure experiments revealed that the Cytotoxicity of 0.1 JIMMMC, as measured by clonoge...

Journal: :Cancer research 1992
R R Perry B R Greaves U Rasberry S C Barranco

Glutathione (GSH) has been shown to modulate the cytotoxicity of a variety of chemotherapeutic agents. The effect of mitomycin C (MMC) treatment duration and the effect of GSH depletion on in vitro cytotoxicity against the human colon cancer cell line HT-29 was studied under aerobic conditions. Continuous-exposure experiments revealed that the cytotoxicity of 0.1 microM MMC, as measured by clon...

Journal: :The European respiratory journal 1999
P Gosset B Wallaert A B Tonnel C Fourneau

Reactive oxygen intermediates exert signalling functions and modulate gene transcription, particularly for pro-inflammatory cytokines. Since exogenous as well as endogenous thiols could be potent inhibitors of the production of cytokines, the effects of N-acetylcysteine (NAC), glutathione (GSH) and modulated GSH synthesis on the production of tumour necrosis factor (TNF)-alpha, interleukin (IL)...

Journal: :The Journal of biological chemistry 2003
Santiago Canals Maria José Casarejos Sonsoles de Bernardo Eulalia Rodríguez-Martín Maria Angeles Mena

Glutathione (GSH) depletion is the earliest biochemical alteration shown to date in brains of Parkinson's disease patients. However, data from animal models show that GSH depletion by itself is not sufficient to induce nigral degeneration. We have previously shown that non-toxic inhibition of GSH synthesis with l-buthionine-(S,R)-sulfoximine in primary midbrain cultures transforms a nitric oxid...

Journal: :Hypertension 2000
N D Vaziri X Q Wang F Oveisi B Rad

Several recent studies have shown that certain forms of genetic or acquired hypertension are associated with oxidative stress and that animals with those types of hypertension respond favorably to antioxidant therapy. We hypothesize that oxidative stress may cause hypertension via (among other mechanisms) enhanced oxidation and inactivation of nitric oxide (NO). To test this hypothesis, Sprague...

Journal: :International journal of oncology 2013
Bo Ra You Woo Hyun Park

Trichostatin A (TSA) as a HDAC inhibitor can regulate many biological properties including apoptosis and cell proliferation in various cancer cells. Here, we evaluated the effect of TSA on the growth and death of HeLa cervical cancer cells in relation to reactive oxygen species (ROS) and glutathione (GSH) levels. Dose- and time-dependent growth in...

Journal: :Blood 1991
M D Scott L Zuo B H Lubin D T Chiu

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is characterized by the loss of NADPH and enhanced erythrocyte oxidant sensitivity. Historically, it has been theorized that the elevated oxidant sensitivity of G6PD-deficient erythrocytes arises as the direct consequence of decreased intracellular glutathione (GSH) concentrations. To directly investigate the basis of G6PD deficiency oxidant s...

Journal: :Blood 1992
R Silber C M Farber E Papadopoulos D Nevrla L Liebes M Bruck R Brown Z N Canellakis

Glutathione (GSH) content may be the major determinant of a cell's sensitivity to cytotoxic alkylating agents. In the present study, the GSH concentration was determined in lymphocytes isolated from the blood of normal subjects and patients with chronic lymphocytic leukemia (CLL). Comparable levels were found in both types of cells. Incubation for 20 hours led to a decrease in GSH to 51% of bas...

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