Transforming growth factor-beta(1) (TGF-beta(1)) is expressed in the adult and embryonic vasculature; however, the biological consequences of increased vascular TGF-beta(1) expression remain controversial. To establish an experimental setting for investigating the role of increased TGF-beta(1) in vascular development and disease, we generated transgenic mice in which a cDNA encoding a constitut...

We quantified benthic diatom diversity in streams the Miellajokka catchment, about 200 km north of Arctic circle Sweden. Beta among sites was related to local-scale environmental heterogeneity (occurring on order 1 or less), and its magnitude equal (Sørensen Index = 0.62) levels previously reported for rivers regional gradients across hundreds kilometres Fennoscandia. Species turnover dominant ...

We analyze a generalized Gross-Pitaevskii (GP) equation involving a paraboloidal trap potential in D space dimensions and generalized to a nonlinearity of order 2n+1. For attractive coupling constants collapse of the particle density occurs for Dn>/=2 and typically to a delta function centered at the origin of the trap. By introducing a special variable for the spherically symmetric solutions, ...

Serum-free mouse embryo (SFME) cells, derived in medium in which serum is replaced with growth factors and other supplements, display distinctive properties: (i) SFME cells do not lose proliferative potential or show gross chromosomal aberration upon extended culture, (ii) these cells depend on epidermal growth factor for survival; and (iii) SFME cell proliferation is reversibly inhibited by se...

BACKGROUND We tested the hypothesis that the fetal-placental relationship scales allometrically and identified modifying factors of that relationship. MATERIALS AND METHODS Among women delivering after 34 weeks but prior to 43 weeks' gestation, 24,601 participants in the Collaborative Perinatal Project (CPP) had complete data for placental gross proportion measures, specifically, placental we...

A computational model of myelin basic protein (MBP) has been constructed based on the premise of a phylogenetically conserved beta-sheet backbone and on electron microscopical three-dimensional reconstructions. Many residues subject to post-translational modification (phosphorylation, methylation, or conversion of arginines to citrullines) were located in loop regions and thus accessible to mod...

The pathology induced by the nematode Camallanus cotti in the aquarium fishes Beta splendens (beta fish) and Poecilia reticulata (guppy) consisted of gross and microscopic lesions, the former characterized by abdominal swelling with reddish parasites protruding from the anus in both fish hosts and the latter, similar in the beta fishes and guppies, by hemorrhage, congestion, edema, a few glandu...