The migration of vascular endothelial cells under flow can be modulated by the addition of chemical or mechanical stimuli. The aim of this study was to investigate how topographic cues derived from a substrate containing three-dimensional microtopography interact with fluid shear stress in directing endothelial cell migration. Subconfluent bovine aortic endothelial cells were seeded on fibronec...

Biomimetic strategies were employed to promote directional outgrowth of neurites in vitro by using a synergistic combination of physical, chemical, and cellular cues. Compression molded and solvent cast biodegradable polymer substrates made of poly(D,L-lactic acid) were micropatterned to form grooves on the substrate surfaces. Laminin was localized in the grooves, and rat sciatic Schwann cells ...

The main objective of this research is to improvethe design and performance of the polyurethane foam-filled thin-walled aluminum grooved circular tubes using multi-response optimization (MRO) technique. The tubes are shaped with the inner and the outer circular grooves at different positions along the axis. For this aim, several numerical simulations using ABAQUS finite element explicit code ar...

BACKGROUND The size and weight of hypertrophied breast can cause both physical and psychological problems. Although the majority of these problems can be solved with breast reduction surgery, the particular problem of development of brassiere strap grooves on the shoulders due to the weight of the breasts cannot be corrected with this method. OBJECTIVES Breast reduction surgery focuses only o...

The purpose of this study was to evaluate the movement of gutta-percha into lateral grooves and depressions in the apical 7 mm of a root canal by using the System B Heat Source for the continuous wave of condensation and the Obtura II for the backfill. A split-tooth model was constructed with lateral grooves and dentin depressions prepared at 1, 3, 5, and 7 mm from working length (WL). The stud...

A novel type of capillary channel fibers (CCFs) containing eight open grooves with depth of 5-15 microm and width of 10 microm were tested for their use in tissue engineering as matrices that provide topographical guidance to neo-tissue development. The matrices fabricated from fibers of poly(l-lactic acid) (PLA) and polyethylene terephthalate (PET) were seeded with rat skin fibroblasts (RSFs) ...

The environment-sensitive fluorophore dan (6-dimethylamino-2-acyl-naphthalene)- modified dC or dG bases were introduced into the Z-DNA forming sequence. It was demonstrated that both grooves of Z-DNA are more hydrated than those of B-DNA. Dan will be useful for probing the microenvironments in the grooves among the DNA polymorphs.

Retraction fibers (RFs) determine orientation of the cell division axis and guide the spreading of daughter cells. Long and unidirectional RFs, which are especially apparent during mitosis of cells in three-dimensional (3D) environments, enable improved control over cell fate, following division. However, 3D gel environments lack the cues necessary for predetermining the orientation of RFs to d...

Background: Periodontitis is primarily a dental plaque induced inflammatory disease, local factors that facilitate the accumulation of bacteria may contribute to the progression of the disease. Periodontal disease is not a single entity nor is there a single causative factor that elicits a consistent periodontal response. Dental abnormalities such as palatal grooves and cervical enamel projecti...