Histone deacetylases (HDACs) have emerged as important drug targets in epigenetics. The most common HDAC inhibitors use hydroxamic acids as zinc binding groups despite unfavorable pharmacokinetic properties. A two-stage protocol of M05-2X calculations of a library of 48 fragments in a small model active site, followed by QM/MM hybrid calculations of the full enzyme with selected binders, is use...

Melt pelletization experiments with sodium valproate as a hygroscopic drug were performed in a laboratory scale high shear mixer. In the current part, the effect of altering the binder liquid properties (using different binders, varying the temperature, or adding highly dispersed silicon dioxide to the molten binder) on the pellet size, size distribution and the growth rate was studied. Three m...

This work aims to improve the rutting and fatigue cracking resistance of asphalt binders using selected nanoor micro-sized materials and to shed light on the microstructure changes induced by such modification to asphalt binders. The four modifiers (Nanomer I.44P, carbon microfiber, non-modified nanoclay and polymer modified nanoclay) were added into the control asphalt binder (PG 58-34). The S...

Hyperphosphatemia and secondary hyperparathyroidism are common complications of ESRD (chronic kidney disease stage 5) that, when untreated, may result in increased morbidity and mortality. Hyperphosphatemia and hypercalcemia have been associated with increased coronary artery calcification. Achieving control of serum phosphorus without increasing serum calcium is an important goal for patients ...

This work describes the preparation of concentrated alumina suspensions based on bio-sourced additives with a low environmental impact and rheological properties adapted to tape casting process. Natural polysaccharides extracted from plants fruits (pectin, psyllium…) were characterized (molar weight) identified as promising binders for substituting classical organic petrochemical industry. The ...

Natural gums are economical, easily available, and useful as tablet binders. In the present investigation, an attempt was made to formulate Ofloxacin tablets using three natural binders, namely Acacia arabica, Hibiscus esculentus, and xanthan gum. Such six batches of Ofloxacin tablets were prepared by using different types and amounts of the natural binders by the wet granulation method. The ta...

Abdurins are a novel antibody-like scaffold derived from the engineering of a single isolated CH2 domain of human IgG. Previous studies established the prolonged serum half-life of Abdurins, the result of a retained FcRn binding motif. Here we present data on the construction of large, diverse, phage-display and cell-free DNA display libraries and the isolation of high affinity binders to the c...

Bio-oil is a dark brown, mobile liquid derived from the thermo-chemical processing of bio-mass. Bio-oils generally contain water and lignin. Lignins are highly-available, well-studied carbohydrate derivative known for their antioxidant properties. For asphalt pavements, oxidation can cause deterioration, a longterm aging process, and eventually result in cracking. Therefore, bio-oil could poten...

In this critical review, binders for electrochemical supercapacitors are introduced and current technologies on the preparation of binders are reviewed in detail. Different types of materials for binder preparation are reviewed by comparing their advantages, disadvantages, and performance with active materials in ES electrodes. Several new trends for the future development of binder preparation...

Many nephrologists feel threatened by the allegation that, in patients with chronic renal failure, treatment with calcium-based phosphate binders (calcium acetate and calcium carbonate) may induce coronary artery and cardiac calcification, thereby imposing a greater risk for death compared with sevelamer, a non-calcium-based binder. Acknowledging that drug manufacturers are not unaware of the m...