BACKGROUND Glucocorticoids are potent anti-inflammatory agents commonly used to treat inflammatory diseases. They convey signals through the intracellular glucocorticoid receptor (GR), which upon binding to ligands, associates with genomic glucocorticoid response elements (GREs) to regulate transcription of associated genes. One mechanism by which glucocorticoids inhibit inflammation is through...

Introduction: Susceptibility-weighted imaging (SWI) has been utilized as a useful contrast mechanism in MRI that accentuates the paramagnetic properties of blood products (1,2). With the use of both magnitude and phase images, SWI can provide improved conspicuity of venous blood vessels and other sources of susceptibility effects (2). Typically, the SWI acquisition uses a high-resolution, three...

Composite coiled tubing is an emerging technology in the oil & gas sector that presents important advantages compared to the steel coiled tubing and conventional drilling. The composite tube has reduced weight, allowing extended reach and improved fatigue life. An additional advantage resides in the fact that the coiled tube wall can contain and protect additional functional elements, such as e...

In an earlier memo [RFC 1701], we described GRE, a mechanism for encapsulating arbitrary packets within an arbitrary transport protocol. This is a companion memo which describes the use of GRE with IP. This memo addresses the case of using IP as the delivery protocol or the payload protocol and the special case of IP as both the delivery and payload. This memo also describes using IP addresses ...

A vast amount of usable electronic data is in the form of unstructured text. The relation extraction task aims to identify useful information in text (e.g., PersonW works for OrganisationX, GeneY encodes ProteinZ) and recode it in a format such as a relational database that can be more effectively used for querying and automated reasoning. However, adapting conventional relation extraction syst...

The paper presents the numerical analysis of failure pressure wall loss defect metallic pipelines and validate it with experimental results. An optimization composite thickness for repair pipeline is also carried out using analysis. A nonlinear explicit FE code constitutive models steel material to modelling was used. Three different cases: non-defective pipe, defective pipe repaired are consid...

This paper presents the approach for the assessing of the operational reliability of a multi-layer thick-walled tube made of rubber with textile reinforcement. The analysis of the fatigue accumulation process is carried out within the framework of the concept of the continuum mechanics of damage. The mathematical model, which takes into account the accumulation of damages in case of a random sp...

OBJECTIVE The purpose of this study was to evaluate the feasibility and diagnostic accuracy of a combined spoiled gradient-echo (sGRE) and tagged gradient-echo (SPAMM-GRE) protocol for detection of coronary artery disease (CAD) during high-dose dobutamine stress at 3 T. METHOD The study protocol was approved by the local ethics committee. For stress testing, a standard high-dose dobutamine pr...

This paper presents a Conceptual Graph (CG) framework to the Generation of Referring Expressions (GRE). Employing Conceptual Graphs as the underlying formalism allows a rigorous, semantically rich, approach to GRE. A number of advantages over existing work are discussed. The new framework is also used to revisit existing complexity results in a fully rigorous way, showing that the expressive po...