This paper describes the association of two unusual side effects of treatment with isotretinoin for severe acne: paronychia and excess granulation tissue in the nails furrows. We report a case of male patient aged 19 years, who in the course of the 36th week of treatment with isotretinoin for acne grade III showed erythema, edema, excess granulation tissue and onychocryptosis in various nail be...

Wound healing is a complex response of the organism aiming to restore tissue integrity and organ function. In skin, vascular and inflammatory changes predominate for the first 3-5 days after wounding. The following granulation phase is characterized by new connective tissue production and re-epithelialization (1). In the mid-phase of cutaneous tissue repair, fibroblasts that have invaded the gr...

Purpose: The fruits of Limonia acidissima Linn are used traditionally in India for the treatment of tumours, asthma, wounds, cardiac debility and hepatitis. The purpose of the present study was to evaluate the wound healing activity of the methanol extract of its fruit pulp (MELA) in incision, excision and dead-space wound models. Methods: Albino rats of either sex were divided into four groups...

Endotracheal and endobronchial stenting, particularly with uncovered stents, can be complicated by stent fracture, granulation tissue formation, direct airway injury, and airway obstruction. While stent removal is possible, it can result in significant complications and long-term benefit is not guaranteed. Argon plasma coagulation can be employed to trim fractured stent fragments and remove gra...

Corticosteroids are not indicated in wound healing, but the intralesional and topical administration of these agents has been described to control tissue overgrowth in humans. The aim of the present study was to assess the use of topical corticosteroids to control preand post-surgical tissue overgrowth in a 5-year-old male Belgian shepherd weighing 33.5 kg. We report successful use of topical a...

Granulation-tissue fibroblasts are phenotypically unique cells that play an important role in wound repair and the development of chronic inflammatory lesions in connective tissue. In the present study, we compared proteoglycan, type I, and type III procollagen gene expression by granulation-tissue fibroblasts from wound and chronically inflamed tissues with normal gingival fibroblasts. We also...

Endobronchial fires are a rare complication of Nd-YAG laser photoresection. Short-term morbidity is secondary to sloughing mucosa and mucous plugging. Aggressive pulmonary hygiene, including frequent bronchoscopies and possibly a tracheostomy, may be required. The major long-term complication is obstruction of the airways from granulation tissue. Long-term follow-up is required to evaluate and ...

1. The intracellular volume in granulation tissue was about 15% of the total urea space. 2. The experimental granuloma has a greater ability to retain amino acids during the proliferation phase than later during the synthesis of collagen. 3. The synthesis of collagen and other proteins by granulation tissue is related to the concentrations of proline and glutamic acid in the medium. 4. The rate...

Ethanolic extract of leaves of O. sanctum was investigated for normal wound healing and dexamethasone depressed healing using incision, excision and dead space wound models in albino rats. The extract of O. sanctum significantly increased the wound breaking strength in incision wound model. The extract treated wounds were found to epithelialize faster and the rate of wound contraction was signi...

Mutations in the laminin-332 (α3Aβ3γ2) genes cause junctional epidermolysis bullosa (JEB), a recessively inherited disease characterized by blistering and altered wound repair. In addition, specific mutations that affect the N-terminus of the α3A chain cause a JEB-related non-blistering condition characterized by chronic production of granulation tissue, suggesting a critical role of this regio...