www.landesbioscience.com Cell Cycle 3575 BRCA1 is a hereditary breast cancer susceptibility gene. BRCA1 germ-line mutation carriers have greatly increased lifetime risks for development of breast cancer. Strikingly, BRCA1 mutations are synonymous with incidence of basal-like breast cancer, with characteristic expression of basal cell markers, including cytokeratins (CKs) 5/6 and CK17. This uniq...

More than 170 assembly factors aid the construction and maturation of yeast ribosomes. After these factors' functions are completed, they must be released from preribosomes. In this issue, Ulbrich et al. (2009) describe a mechanochemical process through which the AAA ATPase Rea1 induces release of an assembly protein complex from preribosomes.