نتایج جستجو برای: graft vs host reaction
تعداد نتایج: 902489 فیلتر نتایج به سال:
The efficacy, safety, and cost of prostaglandin E1 (PGE1) in the treatment of severe intermittent claudication was studied by comparing a long-term treatment protocol (LTP) with a short-term treatment protocol (STP) in a randomized 20-week study. The study included 109 patients (96 completed the study) with an average total walking distance of 65.5 +/- 8 m (range 20-109). Phase 1 was a 2-week r...
Cell-mediated immunity in vivo results in allograft destruction, in graft versus host reactions following bone marrow transplantation, in delayed type hypersensitivity responses to mycobacteria and other antigens, in autoimmune or autoaggressive diseases and in immunity to tumors, allogeneic or syngeneic.1.2 Natural cellular immunity-also known as cellular natural killing (CNK)-has been describ...
Normal engraftment of bone marrow transplants depends on histocompatibility between donor and recipient. In this case reconstitution of hemopoiesis and lymphopoiesis in the mouse spleen is correlated with transient biopterin synthesis in these cells. Allogeneic bone marrow progeny cells undergo donor cell proliferation in the spleen prior to the incidence of graft-versus-host reaction. These ce...
The mixed lymphocyte culture (MLC) test has been regarded as an in vitro model of the recognition or sensitization phase of the homograft or graft-versus-host reaction. It has been suggested that the graft-versus-host response in vivo is less in xenogeneic combinations than in allogeneic ones and that there is a similar quantitative relationship in MLC responses. Given the above interpretation ...
Drug-induced toxic epidermal necrolysis (TEN) and acute cutaneous graft-versus-host reaction (GVHR) under immunopreventive therapy share some histopathological resemblance. So far, there are no serum biomarkers and no immunohistochemical criteria distinguishing with confidence and specificity the skin lesions of TEN and GVHR. Both diseases present as an inflammatory cell-poor necrotic reaction ...
The disparity index is an expression of histocompatibility difference between two siblings with identical human leukocyte antigen (HL-A) type who are nonreactive in mixed leukocyte culture (MLC) test. This index is derived from a third-party MLC test. The disparity index was found to be correlated with the severity of graft-versus-host reaction in bone marrow transplantation between HL-A-identi...
Mice of the low leukemia (BALB/cJ x A/J)F1 hybrid (CAF1) strain express B-and N-tropic infectious murine leukemia virus (MuLV) after the age of 6 mo. Initation of a protracted immunological disorder, the graft-versus-host reaction (GVHR), at 7 wk of age, accelerates the induction of both these mouse-tropic endogenous viruses, and preferentially enhances the replication of B-tropic MuLV. The ear...
Recently, evidence has been gathered showing that the H-2 complex of tlic mouse consists of only two histocompatibility genes (regions), H-2K and H-2D (Klein & Shreffler 1972). The rest of the H-2 regions described in the literature (C,V,E,A) are probably serological artifacts. Kychlikovi and co-workers ( 197 1 ) reported that significant transformation of allogeneic lymphocytes in mixed cultur...
Regulatory T (Treg) lymphocytes are important mediators of the allogeneic immune response, although the mechanisms by which they are controlled are not fully understood. Studies conducted in mice, including a recent article in Immunity by Laurence et al., have shown that STAT3 is an important factor involved in the instability of natural Treg (nTreg) lymphocytes and the generation of induced Tr...
Serum IgE concentrations estimated in 25 bone marrow transplant recipients during episodes of infection or graft versus host disease, or both, were raised not only in some patients with acute graft versus host disease but also in many patients with infection. Raised values were not seen in chronic graft versus host disease. The routine estimation of serum IgE in bone marrow transplant recipient...
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