Background: A demyelinating lesion can present as a space occupying in Magnetic Resonance Imaging (MRI) brain. Lesions that have diameter greater than 2 cm is referred tumefactive lesion. These lesions mimic brain tumor, namely glioma or primary central nervous system lymphoma. Case presentation: We two female patients over 30 years old who presented with limb weakness. Their MRI demonstrated t...

In brain tumors, delivering nanoparticles across the blood-tumor barrier presents major hurdles. A clinically relevant MRI contrast agent, GdDOTA and a near-infrared (NIR) fluorescent dye, DL680 were conjugated to a G5 PAMAM dendrimer, thus producing a dual-mode MRI and NIR imaging agent. Systemic delivery of the subsequent nano-sized agent demonstrated glioma-specific accumulation, probably du...

Abstract OBJECTIVE MRI is gold standard for the diagnosis, surgery and radiation therapy of patients with high-grade glioma. Amino acid PET useful in gliomas without contrast enhancement but it unknown whether better identifies foci than T1-sequence or improve definition high grade glioma infiltration related to T2/Flair images. METHODS More 400 biopsy specimens from twenty-three suspected were...

To determine the frequency of progressive MRI lesions shortly after radiotherapy for glioma with spontaneous improvement or stabilization, the authors studied a cohort of patients treated within two prospective phase III trials with radiotherapy only. In 9 out of 32 patients, the first post-radiotherapy MRI showed progressive enhancement. In 3 of these 9 the MRI improved or stabilized for 6 mon...

PURPOSE To demonstrate the capability of the fractional motion (FM) model for describing anomalous diffusion in cerebral gliomas and to assess the potential feasibility of FM for grading these tumors. METHODS Diffusion MRI images were acquired from brain tumor patients using a special Stejskal-Tanner diffusion sequence with variable diffusion gradient amplitudes and separation times. Patients...

BACKGROUND Categorical grading and other measurable MRI parameters are frequently utilised for predicting the outcome of hamstring injuries. However, the reliability and smallest detectable difference (SDD) have not been previously evaluated. It therefore remains unclear if the variability in previously reported results reflects reporting variation or actual injury status. METHODS 25 hamstrin...

STUDY DESIGN A 2-part cadaveric study. OBJECTIVES Part 1: To assess the reliability of a semiquantitative classification system for grading lumbar spine foraminal stenosis and the variability in magnetic resonance imaging (MRI) examinations carried out in different institutions. Part 2: to assess the difference between the foraminal measurements carried out on MRI images and on cadaveric spec...

Abstract Gliomas of the cerebellum are rare in adults, and their natural history and clinical behavior are not well known. Because cerebellar glioma is not usually diagnosed until clinical symptoms have appeared, no reports have described the developmental process of new cerebellar gliomas. We describe a case of de novo cerebellar anaplastic astrocytoma in which the developmental process was de...

Surgical resection is the primary mode for glioma treatment, while gross total resection is difficult to achieve, due to the invasiveness of the gliomas. Meanwhile, the tumor-resection region is closely related to survival rate and life quality. Therefore, we developed optical/magnetic resonance imaging (MRI) bifunctional targeted micelles for glioma so as to delineate the glioma location befor...

Magnetic resonance spectroscopy and diffusion magnetic resonance imaging (MRI) characteristics of human intracranial glioma were studied. Present knowledge suggests a hypothetical inverse relationship between the characteristic choline signal intensity elevation and the apparent diffusion coefficient (ADC) in glioma. Twenty cases of glioma were examined with diffusion-weighted echoplanar imagin...