نتایج جستجو برای: gossypol

تعداد نتایج: 670  

2006
Wen-Qing Wang Rong Li Qing-Xian Bai Yu-Hong Liu Wei-Ping Zhang Juan-Hong Wang Zhe Wang Yuan-Fei Li Xie-Qun Chen Gao-Sheng Huang

The main treatment of leukemia is traditional radiochemotherapy, which is associated with serious side effects. In the past twenty years, differentiation was found as an important effective measure to treat leukemia with fewer side effects. Gossypol, a natural compound which has been used as an effective contraceptive drug, has been proposed to be a potent drug to treat leukemia, but the differ...

Journal: :Archives of biochemistry and biophysics 1984
K L Olgiati D G Toscano W M Atkins W A Toscano

Gossypol, a polyphenolic binaphthalene -dialdehyde reputed to exert contraceptive action in males, reversibly inhibits adenylate cyclase [ATP pyrophosphate lyase (cyclizing), EC 4.6.1.1] in a concentration-dependent manner. In membranes prepared from a variety of organs, the half-maximal inhibitory concentration (IC50) ranges from 75 microM (rat Leydig tumor cells) to 250 microM (rat liver memb...

Journal: :Journal of animal science 2002
J Velasquez-Pereira C F Aréchiga L R McDowell P J Hansen P J Chenoweth M C Calhoun C A Risco T R Batra S N Williams N S Wilkinson

Superovulated Hereford-Angus crossbred heifers (average 397 kg BW) were used to test the effect of feeding cottonseed meal (gossypol) and vitamin E on embryo quality and ovarian characteristics. Twenty-four heifers were assigned randomly to four treatments with six heifers per treatment. Treatments were the following dietary supplements: 1) SBM (soybean meal + 30 IU vitamin E/kg of diet DM); 2)...

2013
T. Annamalai G. Venkateswara Rao

Bioassay guided purification of methanolic extract of the bark of the plant, Thespesia populnea yielded a naphthalene derivative, (+)-gossypol (1). The structure of compound, (+)-gossypol has been established based on its physical and spectral data (UV, IR, H & C NMR and Mass). The compound has been shown moderate elastase inhibition activity when compared with control compound, ursolic acid.

2004
A. S. EL-SHARAKY

The neutral and polar lipids of serum and seminal fluid of male rats were investigated under .t~e effect of gossypol acetic acid, apogossypol and gossypolone. The. total phospholipids. and. the neutral serum l.Ipids showed positive and negative significant correlation with the duratiOn .of gossypol acetic acid treatment, :espe~tively. At. the same time, free fatty acids content significantly in...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006
Xiaobo Lei Yingyu Chen Guanhua Du Wenyu Yu Xiaohui Wang Hong Qu Bin Xia Hongping He Jianhua Mao Weixing Zong Xudong Liao Maryam Mehrpour Xiaojiang Hao Quan Chen

Cells without Bak and Bax are largely resistant to apoptosis, despite the presence of other key components of the apoptotic machinery. We screened 7,800 natural compounds and found several that could specifically induce caspase activation and the release of cytochrome c (cyto c) in the bak(-/-)/bax(-/-) cells. One of these was gossypol, a polyphenolic compound naturally found in cottonseed that...

Journal: :International Journal of Andrology 1982

2014
Lixu Jin Yuling Chen Xinlin Mu Qingquan Lian Haiyun Deng Renshan Ge

Ovarian cancer is a major cause for death of gynecological cancer patients. The efficacy of traditional surgery and chemotherapy is rather compromised and platinum-resistant cancer recurs. Finding new therapeutic targets is urgently needed to increase the survival rate and to improve life quality of patients with ovarian cancer. In the present work, phosphoproteomic analysis was carried out on ...

2017
Chaohua Tang Qingshi Meng Kai Zhang Tengfei Zhan Qingyu Zhao Sheng Zhang Junmin Zhang

Gossypol is an antiproliferative drug with limited use due to its hemolytic toxicity. In this study, accelerated hemolysis was observed in the cows treated with gossypol. Comparative metabolomics were used to gain responsive pathways in the red blood cell (RBC) to the treatment, which were crossly validated by parallel iTRAQ-based proteomic analysis and enzyme activity assay. We found that goss...

2016
Joon Hee Kang Seon-Hyeong Lee Jae-Seon Lee Boas Nam Tae Wha Seong Jaekyoung Son Hyonchol Jang Kyeong Man Hong Cheolju Lee Soo-Youl Kim

Among ALDH isoforms, ALDH1L1 in the folate pathway showed highly increased expression in non-small-cell lung cancer cells (NSCLC). Based on the basic mechanism of ALDH converting aldehyde to carboxylic acid with by-product NADH, we suggested that ALDH1L1 may contribute to ATP production using NADH through oxidative phosphorylation. ALDH1L1 knockdown reduced ATP production by up to 60% concomita...

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