The present study was conducted to characterize the nature and pattern of serum and secretory antibody responses to N. gonorrhoeae by haemagglutination inhibition, opsonization, and immunofluorescence techniques in male and female patients with different clinical manifestations of gonorrhoea. Most male patients with acute gonococcal infection developed serum IgG and, less frequently, IgM antibo...

The occurrence of skin lesions in gonococcal bacteraemia is well recognized and well documented (Keil, 1938; Abu-Nassar, Hill, Fred, and Yow, 1963; Kvorning, 1963; O'Sullivan, 1964; Ackerman, Miller, and Shapiro, 1965; Fred, Eiband, Martincheck, and Yow, 1965; Bj6rnberg and Gisslen, 1966). Less well documented is the occurrence of lesions due to direct implantation of gonococci on the skin, eit...

The primary human urethral epithelial cells developed by our laboratory have been immortalized by transduction with a retroviral vector expressing the human papillomavirus E6E7 oncogenes. Analysis of telomerase expression and comparison to that in primary cells revealed detectable levels in the transduced human urethral epithelial cells. Immortalized urethral cells could be passaged over 20 tim...

Gonorrhea is the second most prevalent sexually transmitted infection globally [1]. Despite the public health efforts to control gonorrhea for 70 years, these infections remain a significant public health concern. In 2015, a total of 395, 216 cases of gonorrhea were reported in the United States [2]. World widely, 106.1 million people are affected by gonococcal infections annually [3]. If gonoc...

Although known to occur in the past, it is only in recent years that the incidence and importance of oral infection by the gonococcus has come to be assessed. The first case of gonococcal pharyngitis was described by Fiumara, Wise, and Many (1967). Thatcher, McCraney, Kellogg, and Whaley (1969) found no gonococci in the urethra and rectum in a routine screening by culture of 505 military subjec...

BACKGROUND/OBJECTIVES Recently, the sac-4 gene in Neisseria gonorrhoeae was postulated to increase the risk of developing mixed gonococcal and chlamydial infection. The aims of this study were to determine the frequency of the sac-4 gene in a larger sample of isolates of different serovars and to assess the prevalence of sac-4 in gonococcal isolates from patients with and without coexisting chl...

In 1979 an indirect haemagglutination test (gonococcal antibody test) using gonococcal pilus antigen replaced the gonococcal complement fixation test as our routine procedure to show gonococcal antibodies. In the diagnosis of current gonorrhoea the sensitivity of the gonococcal antibody test was far superior to that of the gonococcal complement fixation test (about 55% versus 9% for first episo...

Disseminated gonococcal infection (DGI) occurs in only a small minority of mucosal infections with Neisseria gonorrhoeae. Clinical manifestations of DGI include skin lesions, fever and musculoskeletal involvement. Articular manifestations include arthralgia, tenosynovitis, peri-arthritis and arthritis. Useful imaging techniques in DGI are multiphase bone scintigraphy and grey-scale ultrasonogra...

Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection (STI) gonorrhea, is a growing public health threat for which a vaccine is urgently needed. We characterized the functional role of the gonococcal MetQ protein, which is the methionine binding component of an ABC transporter system, and assessed its potential as a candidate antigen for inclusion in a gonococcal vacc...