Plants have been used as a traditional medicine for the treatment of malaria. Plants may provide drugs directly such as quinine from cinchona bark or they may provide template molecules on which to base further new structures by organic synthesis—artemisinin from Artemisia annua. At the NIMR, efforts are being made to do primary screening of crude extracts of plant products to screen different ...

The anticoccidial effect of Artemisia annua and Pimpinella anisum on Eimeria tenella infection (1500 oocysts/chicken) has been studied. The products were used as oil administered 7.5% in water and as powder 1.5% in food. The effects of A. annua and P. anisum on E. tenella infection were assessed by clinical signs, mortality, fecal oocyst shedding, lesional score, body weight gain and feed conve...

Despite the importance of Artemisia annua L. as the only source of the anti-parasitic drug artemisinin, little is known on the effects of biotic and abiotic stress on artemisinin accumulation. Water deficit is the most limiting factor on plant growth, however it can trigger secondary metabolite accumulation, depending on the plant growth stage and intensity. A. annua cultivated in growth chambe...

Artemisinin is the active antimalarial compound obtained from the leaves of Artemisia annua L. Artemisinin, and its semi-synthetic derivatives, are the main drugs used to treat multi-drug-resistant Plasmodium falciparum (one of the human malaria parasite species). The in vitro susceptibility of P. falciparum K1 and 3d7 strains and field isolates from the state of Amazonas, Brazil, to A. annua i...

Plants are sessile organisms, and they can not move away under abiotic or biotic stresses. Thus plants have evolved a set of genes that response to adverse environment to modulate gene expression. In this study, we characterized and functionally studied an ERF transcription factor from Artemisia annua, AaERF1, which plays an important role in biotic stress responses. The AaERF1 promoter had bee...

background: giardiasis is a one of the most prevalent intestinal parasitic diseases in human, treatment of this disease through medicinal plants is very important since parasite resistance to chemical drugs exists. thus, in this study, the in vitro anti-giardial activity of chloroformic extract of tanacetum parthenium and artemisia annua on cyst and trophozoite of giardia lamblia were separatel...

Background: Giardiasis is a one of the most prevalent intestinal parasitic diseases in human, treatment of this disease through medicinal plants is very important since parasite resistance to chemical drugs exists. Thus, in this study, the in vitro anti-giardial activity of chloroformic extract of Tanacetum parthenium and Artemisia annua on cyst and trophozoite of Giardia lamblia were separatel...