In the recent years, application of nanoparticles in diagnosis and treatment of cancer has been the issue of extensive research. Among these studies some have focused on the dose enhancement effect of gold nanoparticles (GNPs) in radiation therapy of cancer. On the other hand, some studies indicated energy dependency of dose enhancement effect, and the others have studied the GNP size effect in...

BACKGROUND Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. OBJECTIVE The aim of this study is to understand characteristics of secondary electrons generated from interaction of gold nanoparticles GNPs with x-rays as a function of nanoparticle size and beam energy and ...

A novel voltammetric sensor based on gold nanoparticles (GNPs) and single-walled carbon nanotubes (SWNTs) composite was developed. The nanocomposite modified electrode was characterized using atoms force microscope (AFM). The electrochemical behavior of meclofenoxate hydrochloride (MFX) was investigated on this sensor. The results indicated that the GNPs/SWNTs modified electrode exhibited effic...

Gold nanorods (GNRs) are considered one of the most promising forms of nanoparticles for nanobiotechnology; however, the problem of their toxicity is currently not resolved. We synthesised GNRs, modified with linear polyethyleneimine (PEI-GNRs), and examined their physicochemical and some biological properties in comparison with GNRs modified with BSA and spherical gold nanoparticles (sGNPs) mo...

Background: Gold nanoparticles (GNPs) have been shown as a good radiosensitizer. In combination with radiotherapy, several studies with orthovoltage X-rays have shown considerable dose enhancement effects. This paper reports the dose enhancement factor (DEF) due to GNPs in 18 megavoltage (MV) beams. Materials and Methods: Different geometrical 50-nm GNPs configurations at a concentrati...

Gold nanoparticles (GNPs) are widely used to detect DNA. We studied the effect of pH on the assembly/disassembly of single-stranded DNA functionalized GNPs. Based on the different binding affinities of DNA to GNPs, we present a simple and fast way that uses HCl to drive the assembly of GNPs for detection of DNA sequences with single nucleotide differences. The assembly is reversible and can be ...

An experimental approach for improving the sensitivity of the surface plasmon resonance (SPR) DNA hybridization sensor using gold nanoparticles (GNPs), modified by specific oligonucleotides, was elaborated. An influence of the ionic strength on the aggregation stability of unmodified GNPs and GNPs modified by the thiolated oligonucleotides was investigated by monitoring a value of light extinct...

Introduction: To date, gold nanoparticles (GNPs) have been demonstrated to have great potential as contrast agent for CT imaging and therapeutics. This study was designed to evaluate any effect on X-ray attenuation that might result from using GNPs with a variety of size, surface chemistries and shapes.   Materials and Methods: Spherical GNPs and gold nanorod...

A one-step rapid and ultrasensitive immunoassay capable of detecting proteins in blood serum is developed using gold nanoprobes and fluorescence correlation spectroscopy (FCS). In this approach we take advantage of the inherent photoluminescence property of gold nanoparticles (GNPs) to develop a fluorophore-free assay to observe binding entities by monitoring the diffusion of bound versus unbou...

objective: due to recent advances in nanotechnology it is now possible to accumulate high atomic-number nanomaterial such as gold nanoparticles (gnps) in cancerous cells and take advantage of their absorbed dose enhancement property as radiosensitizing agents. this study aimed to investigate the absorbed dose enhancement factor due to the presence of pegylated gnps under the irradiation of an m...