نتایج جستجو برای: glycosaminoglycans
تعداد نتایج: 5483 فیلتر نتایج به سال:
We have identified the Drosophila UDP-glucose dehydrogenase gene as being involved in wingless signaling. Mutations in this gene, called kiwi, generate a phenotype identical to that of wingless. UDP-glucose dehydrogenase is required for the biosynthesis of UDP-glucuronate, which in turn is utilized in the biosynthesis of glycosaminoglycans. By rescuing the kiwi phenotype with both UDP-glucurona...
A considerable need exists for improved biomarkers for differential diagnosis, prognosis and monitoring of therapeutic interventions for mucopolysaccharidoses (MPS), inherited metabolic disorders that involve lysosomal storage of glycosaminoglycans. Here we report a simple, reliable method based on the detection of abundant nonreducing ends of the glycosaminoglycans that accumulate in cells, bl...
Glycosaminoglycans (GAGs) are complex carbohydrates that are ubiquitously present on the cell surface and in the extracellular matrix. Interactions between GAGs and pathogens represent the first line of contact between pathogen and host cell and are crucial to a pathogen's invasive potential. Their complexity and structural diversity allow GAGs to control a wide array of biological interactions...
The sugar components of acidic glycosaminoglycans have long been known to be derived from glucose without alteration of the sugar ring (Topper & Lipton, 1953). The discovery of the nucleotide sugars by Caputto et al. (1950) and Park (1952) radically transformed the outlook on the biosynthesis of polysaccharides. It became rapidly apparent, not only that nucleotide sugars were the ‘activated’ do...
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