Within the past few years considerable progress has been made in regard to the possible pathways of phospholipide synthesis in the liver. Kornberg and Pricer (1) have reported that in microsomal fractions of guinea pig liver ar-glycerophosphate is a precursor of phosphatidic acid, which is formed by an acylation of glycerophosphate by coenzyme A derivatives of fatty acid. In a similar manner, K...

We previously reported that Runx2/miR-3960/miR-2861 regulatory feedback loop stimulates osteoblast differentiation. However, the effect of this feedback loop on the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) remains unclear. Our recent study showed that miR-2861 and miR-3960 expression increases significantly during β-glycerophosphate-induced osteogenic transdiffere...

A study of the fine structural localization of the acyltransferases of the monoglyceride and alpha-glycerophosphate pathways for triglyceride synthesis in the intestinal absorptive cell is reported. Glutaraldehyde-fixed tissue was found to synthesize diglyceride and triglyceride from monopalmitin and palmityl CoA, and parallel morphological studies showed the appearance of lipid droplets in the...

The effect of diet on the desaturation of linoleic acid to y-linolenic acid by liver microsomal preparations, on blood glucose and insulin levels, and on activities of glucokinase, hexokinase, pyruvate kinase, and a-glycerophosphate dehydrogenase have been studied. The female rats used in these experiments were maintained on one of the following dietary regimes: (a) fasted, (6) fasted for 96 hr...

1. Loading the isolated perfused liver from well-fed rats with xylitol (20mm) caused a depletion of adenine nucleotides and P(i) and an accumulation of alpha-glycerophosphate. The ATP content fell to 66% of the control value after 10min and to 32% after 80min. The ADP and AMP contents also fell. After 80min 63% of the total adenine nucleotides and 59% of the P(i) had been lost. 2. The alpha-gly...

The effects of diet on the rate of triglyceride synthesis by rat liver homogenates was measured. Changes in triglyceride synthesis were correlated with the level of activity of L-alpha-glycerophosphate acyltransferase, the enzyme catalyzing the first specific reaction in hepatic glycerolipid synthesis. Fasting for 48-72 hr depressed the synthesis of triglyceride from L-alpha-glycerophosphate. H...

Background Limited phosphate (Pi) reserves and the economic adverse environmental impacts of excessive application mineral fertilizers in soils are alarming. Therefore, use organic phosphorus (Porg) is suggested to reduce reliance on chemical fertilizers. Aims There currently little information regarding accessibility Porg N2 fixation plants. present study aims address question what extent subs...