Abstract Background In silico studies further provided predictive binding properties of selected ligands for inhibition target protein. the study, molecular poses Cucurbitacin-E and antioxidant enzymes (glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), peroxidase (GPx) acetylcholinesterase (AChE) Galleria mellonella were determined in silic...

We studied the effects of mexidol (3-oxy-6-methyl-2-ethylpiridine succinate) on antioxidant glutathione system in rat brain mitochondria experimental Parkinson’s disease induced by rotenone administration. Wistar rats were divided into following groups 6 each: I - intact (control); II (3 mg/kg per day) was injected subcutaneously for 2 weeks; III after intoxication, (50 intraperitoneally weeks....

Drought is one of the main abiotic stress factor that limits plant growth and development. effects on Borago officinalis L. (borage) plants in terms physiological antioxidant responses have been evaluated this study. In parallel with purpose, relative rate (RGR), leaf water content (RWC), osmotic potential, chlorophyll fluorescence (Fv/Fm), lipid peroxidation, hydrogen peroxide (H2O2) level, su...

Global coral reef decline is largely driven by the breakdown of coral-algal symbiosis during temperature stress. Corals can acclimatize to higher temperatures, but cellular processes underlying this ability are poorly understood. We show that preconditioning-based improvements in thermal tolerance Pocillopora acuta accompanied increases host glutathione reductase (GR) activity and gene expressi...

The aim of this study was to determine the effect of a prolonged high-fat (HF) on thiol-disulfide homeostasis via the activity of the glutathione redox-system (GRS) in rat blood and liver. Methods: The experiment was conducted on male Wistar rats. They were divided into groups and fed on the HF diet for 30, 90 and 180 days, respectively. The HF diet consisted of beef fat and cholesterol (19 % a...

This study examined the effect of an antioxidant intervention in biomarkers of inflammation and oxidative stress (OS) in the blood of Down syndrome (DS) children and teenagers during four different stages. A control group was composed by healthy children (n=18), assessed once, and a Down group composed by DS patients (n=21) assessed at the basal period (t0), as well as after 6 months of antioxi...

This study investigated seasonal variations of antioxidant defense enzyme activities: total, manganese, copper zinc containing superoxide dismutase (Tot SOD, Mn SOD, CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST) activity in the liver and white muscle of red mullet (Mullus barbatus). Th...

NADPH transfers reducing power from bioenergetic pathways to thioredoxin reductase-1 (TrxR1) and glutathione reductase (GR) to support essential reductive systems. Surprisingly, it was recently shown that mouse livers lacking both TrxR1 and GR ('TR/GR-null') can sustain redox (reduction-oxidation) homoeostasis using a previously unrecognized NADPH-independent source of reducing power fuelled by...

AIMS Diabetes is considered a state of increased oxidative stress. This study evaluates blood concentrations of selected markers of antioxidant defense in patients with type 2 diabetes. METHODS The study included 80 type 2 diabetes patients and 79 apparently healthy controls. Measured markers included ferric reducing ability of plasma (FRAP), reduced glutathione (GSH), glutathione peroxidase ...

Recently, we have put forward the hypothesis that a decreased concentration of reduced glutathione (GSH) may be implicated in the mechanisms of peroxidative damage to the liver and kidney caused by lead (Pb) and/or ethanol (EtOH). Thus, the aim of the present study was to assess the activities of GSH-related enzymes, such as glutathione peroxidase (GPx), glutathione reductase (GR), and glutathi...