نتایج جستجو برای: glutathione peroxidase gshpx

تعداد نتایج: 63181  

Journal: :Pharmacological reports : PR 2014
Małgorzata Sochacka Joanna Giebułtowicz Małgorzata Remiszewska Piotr Suchocki Piotr Wroczyński

BACKGROUND Selol is a novel organoselenium Se(IV) compound. It reveals lower potential of toxicity than sodium selenite and does not exhibit mutagenic activity. Its antioxidant and anticancer properties including overcoming cancer cell resistance to standard therapy of the drug were proven. This is the first publication describing the influence of Selol 5% on the activity of blood antioxidant s...

Journal: :EXCLI journal 2013
Heba Hosny Mansour

This study investigated the potential protective effects of ginseng on gamma-irradiation-induced oxidative stress and endothelial dysfunction in rats. Twenty four male albino rats were divided into four groups. In the control group, rats were administered vehicle by tube for 7 consecutive days. The second group was administered ginseng extract (100 mg/kg, by gavage) for 7 consecutive days. Anim...

2013
E. Freedman Balz Frei Joseph Loscalzo

GSH peroxidase (Px) catalyzes the reduction of lipid hydroperoxides (LOOH), known metabolic products of platelets and vascular cells. Because interactions between these cells are modulated by nitric oxide (NO) and LOOH inactivate NO, we investigated the effect of GSH-Px on the inhibition of platelet function by the naturally occurring S-nitrosothiol, S-nitroso-glutathione (SNO-Glu). Concentrati...

Journal: :The Biochemical journal 1980
A Boveris H Sies E E Martino R Docampo J F Turrens A O Stoppani

The glutathione peroxidase-glutathione reductase system, an alternative pathway for metabolic utilization of H2O2 [Chance, Sies & Boveris (1979) Physiol. Rev. 59, 527-605], was investigated in Trypanosoma cruzi, an organism lacking catalase and deficient in peroxidase [Boveris & Stoppani (1977) Experientia 33, 1306-1308]. The presence of glutathione (4.9 +/- 0.7 nmol of reduced glutathione/10(8...

Journal: :Infection and immunity 2004
Audrey Brenot Katherine Y King Blythe Janowiak Owen Griffith Michael G Caparon

Glutathione peroxidases are widespread among eukaryotic organisms and function as a major defense against hydrogen peroxide and organic peroxides. However, glutathione peroxidases are not well studied among prokaryotic organisms and have not previously been shown to promote bacterial virulence. Recently, a gene with homology to glutathione peroxidase was shown to contribute to the antioxidant d...

Journal: :The Journal of biological chemistry 1978
R F Burk K Nishiki R A Lawrence B Chance

Two glutathione peroxidase activities have been described in rat liver. One contains selenium and is virtually absent in selenium deficiency. The other seems to be unaffected by selenium status. The selenium-dependent glutathione peroxidase utilizes H,O, and organic hydroperoxides as substrates, but the selenium-independent glutathione peroxidase is much more efficient with organic hydroperoxid...

2012
Rahmat A Khan Muhammad R Khan Sumaira Sahreen

BACKGROUND Rutin is a polyphenolic natural flavonoid which possesses antioxidant and anticancer activity. In the present study the hepatoprotective effect of rutin was evaluated against carbon tetrachloride (CCl₄)-induced liver injuries in rats. METHODS AND MATERIALS 24 Sprague-Dawley male rats were equally divided into 4 groups for the assessment of hepatoprotective potential of rutin. Rats ...

2014
Huda Mohammad Alkreathy Rahmat Ali Khan Muhammad Rashid Khan Sumaira Sahreen

BACKGROUND Sonchus arvesis is traditionally reported in various human ailments including hepatotoxicity in Pakistan. Presently we designed to assess the protective effects of methanolic extract of Sonchus arvesis against carbon tetrachloride induced genotoxicity and DNA oxidative damages in hepatic tissues of experimental rats. METHODS 36 male Sprague-Dawley rats were randomly divided into 6 ...

2010
Othman A. Alshabanah Mohamed M. Hafez Mohamed M. Al-Harbi Zeinab K. Hassan Salim S. Al Rejaie Yosef A. Asiri Mohamed M. Sayed-Ahmed

Doxorubicin is an antibiotic broadly used in treatment of different types of solid tumors. The present study investigates whether L-carnitine, antioxidant agent, can reduce the hepatic damage induced by doxorubicin. Male Wistar albino rats were divided into six groups: group 1 were intraperitoneal injected with normal saline for 10 consecutive days; group 2, 3 and 4 were injected every other da...

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2014

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید