نتایج جستجو برای: glutaryl coa

تعداد نتایج: 26089  

Journal: :Journal of bacteriology 2013
Marc Schürmann Beatrice Hirsch Jan Hendrik Wübbeler Nadine Stöveken Alexander Steinbüchel

The act gene of Variovorax paradoxus TBEA6 encodes a succinyl-CoA:3-sulfinopropionate coenzyme A (CoA)-transferase, Act(TBEA6) (2.8.3.x), which catalyzes the activation of 3-sulfinopropionate (3SP), an intermediate during 3,3'-thiodipropionate (TDP) degradation. In a previous study, accumulation of 3SP was observed in a Tn5::mob-induced mutant defective in growth on TDP. In contrast to the wild...

Journal: :The Journal of biological chemistry 1963
J D BRODIE G WASSON J W PORTER

A number of laboratories (l-4) have investigated the biosynthesis of mevalonic acid from acetate or acetyl coenzyme ,4 by yeast and animal enzyme systems. These investigations have indicated that acetoacetyl coenzyme A and P-hydroxy-P-methylglutaryl coenzyme A glutaryl are intermediates in the formation of mevalonic acid. However, the synthesis in vitro of sterols from acetate by subcellular, r...

Azizollah Pourmahmoudi, Mahboobe Hosseinikia, Mahnaz Mozafari, Mohammad Shafee Talebianpoor, Mohammad Sharif Talebianpoor, Tahereh Vafaiee Nejad,

Background: The present study was conducted to evaluate the effect of curcumin as a flavonoid antioxidant on serum lipid profile, oxidative stress, and blood glucose in experimental models of type 2 diabetes (DM2). Methods: Subcutaneous daily injection of dexamethasone (5 mg/kg/day) for a month was performed to induce DM2. For this purpose, 28 adult male Wistar rats were divided into four group...

2017
Satyajeet Roy Joshua Louis Weinstock Allyse Sachiko Ishino Jefferson Felix Benites Samantha Rachel Pop Christopher David Perez Edvard Adrian Gumbs Jennifer Ann Rosenbaum Mary Kate Roccato Hely Shah Gabriela Contino Krystal Hunter

BACKGROUND Atherosclerotic cardiovascular diseases are the leading cause of death in the United States. A reduction in cholesterol with 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (statin) significantly reduces mortality and morbidity. Statins may be associated with cognitive impairment or dementia. Our aim was to study the association of cognitive impairment or dementia in patients wh...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
S Rao D C Porter X Chen T Herliczek M Lowe K Keyomarsi

In this paper we present the finding that lovastatin arrests cells by inhibiting the proteasome, which results in the accumulation of p21 and p27, leading to G1 arrest. Lovastatin is an inhibitor of hydroxymethyl glutaryl (HMG)-CoA reductase, the rate-limiting enzyme in cholesterol synthesis. Previously, we reported that lovastatin can be used to arrest cultured cells in the G1 phase of the cel...

Journal: :Brain : a journal of neurology 2007
Kevin A Strauss Jelena Lazovic Max Wintermark D Holmes Morton

Despite early diagnosis, one-third of Amish infants with glutaryl-CoA dehydrogenase deficiency (GA1) develop striatal lesions that leave them permanently disabled. To better understand mechanisms of striatal degeneration, we retrospectively studied imaging results from 25 Amish GA1 patients homozygous for 1296C>T mutations in GCDH. Asymptomatic infants had reduced glucose tracer uptake and incr...

Journal: :Human molecular genetics 2008
Britta Keyser Chris Mühlhausen Achim Dickmanns Ernst Christensen Nicole Muschol Kurt Ullrich Thomas Braulke

Glutaric aciduria type 1 (GA1) is an autosomal recessive neurometabolic disorder caused by mutations in the glutaryl-CoA dehydrogenase gene (GCDH), leading to an accumulation and high excretion of glutaric acid and 3-hydroxyglutaric acid. Considerable variation in severity of the clinical phenotype is observed with no correlation to the genotype. We report here for the first time on expression ...

Journal: :Applied and environmental microbiology 2001
M S Elshahed V K Bhupathiraju N Q Wofford M A Nanny M J McInerney

The metabolism of benzoate, cyclohex-1-ene carboxylate, and cyclohexane carboxylate by "Syntrophus aciditrophicus" in cocultures with hydrogen-using microorganisms was studied. Cyclohexane carboxylate, cyclohex-1-ene carboxylate, pimelate, and glutarate (or their coenzyme A [CoA] derivatives) transiently accumulated during growth with benzoate. Identification was based on comparison of retentio...

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