نتایج جستجو برای: glucuronidase
تعداد نتایج: 3231 فیلتر نتایج به سال:
Non-communicable diseases such as gastric inflammatory and the hepatic pathologies are mainly related to bad lifestyle habits recurrent consumption of non-steroidal anti-inflammatory drugs (NSAIDs), excessive intake alcohol, tobacco, steroids (high doses), alkaline agents, strong acid foods, high-fat food, Helicobacter pylori infections, among others. The fruit Opuntia oligacantha C.F. Först va...
Purpose: To investigate the effect of β-glucuronidase on the extraction efficiency of silymarin (mainly as silybin) from spiked human plasma using a sensitive and reproducible high performance liquid chromatography (HPLC) method. Methods: The importance of β-glucuronidase was evaluated by comparing the extraction efficiency of silymarin in β-glucuronidase-treated and untreated plasma samples. I...
The selective inhibition of bacterial β-glucuronidases was recently shown to alleviate drug-induced gastrointestinal toxicity in mice, including the damage caused by the widely used anticancer drug irinotecan. Here, we report crystal structures of representative β-glucuronidases from the Firmicutes Streptococcus agalactiae and Clostridium perfringens and the Proteobacterium Escherichia coli, an...
PMA enhanced release of the azurophil granule enzyme, beta-glucuronidase, as well as lysozyme, from cytochalasin B-treated PMN's exposed to either zymosan particles or C5a. PMA was active at nanomolar concentrations, was not toxic to the cells, and was most effective when present for brief durations (0-1 min) before exposure of the cells to the stimuli. Beta-glucuronidase was not released in ...
Beta-glucuronidase activity was investigated during a 48-h period in which virus replication and changes in cell morphology occurred. Infection of an established line of chimpanzee liver cells with either nononcogenic adenovirus 5 or highly oncogenic adenovirus 12 under one-step growth conditions produced differing patterns of enzyme activity. There was an increase in total activity and also en...
An enzymatically activatable prodrug of doxorubicin was covalently coupled, using click-chemistry, to the hydrophobic core of poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl)-methacrylamide-lactate] micelles. The release and cytotoxic activity of the prodrug was evaluated in vitro in A549 non-small-cell lung cancer cells after adding β-glucuronidase, an enzyme which is present intracellularly i...
The results of cerebrospinal fluid (CSF) biochemical markers were compared with conventional CSF cytology in patients treated for leptomeningeal metastases from extra cranial malignancies. For lumbar CSF, before treatment, no statistically significant difference of the probabilities of being positive was found between CSF cytology and a classification by linear discriminant analysis, based on p...
The present study deals with changes of lysosomal enzyme activity in cultured mouse pertioneal macrophages infected with .five species of mycobacieria. Infection with M tuberculosis raised acid phosphatase activity in macrophages. M bovis BCG and M microti also caused rise in this enzyme activity but not fi-glucuronidase activity. The cells infected with M leprae showed decrease in both acid ph...
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