Lei Zheng1,2, Jiangtao Li2 and Yan Luo3 1The Sidney Kimmel Comprehensive Cancer Center, The Skip Viragh Center for Pancreatic Cancer, The Sol Goldman Pancreatic Cancer Center Department of Oncology, and Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 2Department of Surgery, The Second Affiliated Hospital Zhejiang University College of Medicine, Hangzh...

This review describes major factors that, singly or together, influence the concentration and distribution of D-glucose in mammals, particularly in humans, with emphasis on rest, physical activity, and alimentation. It identifies areas of uncertainty: distribution and concentrations of glucose in interstitial fluid, kinetics and mechanism of transcapillary glucose transport, kinetics and mechan...

Abstract Background Metabolic syndrome and its individual components lead to wide-ranging consequences, many of which affect the central nervous system. In this study, we compared [ 18 F]FDG regional brain metabolic pattern participants with type 2 diabetes mellitus (T2DM) non-DM obese individuals. Methods our prospective 51 patients controlled T2DM (ages 50.6 ± 8.0 years) 45 52.0 9.6 were enro...

Sodium-glucose cotransporter 2 inhibitor (SGLT2i) is a new type of hypoglycemic drug, which can reduce the excitability sympathetic nerve by regulating metabolism energy substrate, electrolyte, tissue fluid and circulating blood volume in ganglion, interfering with inflammation oxidative stress, offering protection to vascular endothelial cells, maintaining vasodilation function, pressure load ...

OBJECTIVE To determine the usefulness of measuring hemoglobin A(1c) (A1C), alone or combined with the fasting glucose test, compared with the oral glucose tolerance test (OGTT) for the reassessment of the carbohydrate metabolism status in postpartum women with a history of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS We evaluated the status of carbohydrate metabolism by pe...

OBJECTIVE Insulin stimulates brain glucose metabolism, but this effect of insulin is already maximal at fasting concentrations in healthy subjects. It is not known whether insulin is able to stimulate glucose metabolism above fasting concentrations in patients with impaired glucose tolerance. RESEARCH DESIGN AND METHODS We studied the effects of insulin on brain glucose metabolism and cerebra...

Oncogenes influence nutrient metabolism and nutrient dependence. The oncogene c-Myc stimulates glutamine metabolism and renders cells dependent on glutamine to sustain viability ("glutamine addiction"), suggesting that treatments targeting glutamine metabolism might selectively kill c-Myc-transformed tumor cells. However, many current or proposed cancer therapies interfere with the metabolism o...