Mutations in the key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetyl-mannosamine kinase, result in distal myopathy with rimmed vacuoles (DMRV)/hereditary inclusion body myopathy (HIBM) in humans. Sialic acid is an acidic monosaccharide that modifies non-reducing terminal carbohydrate chains on glycoproteins and glycolipids, and it plays an important role in cell...

Objective: This study examined the development of nephrons and differentiation juxtaglomerular apparatus (JGA) cells in BALB/c type mouse embryos. Thick thin epon sections were investigated by light microscopy (LM) transmission electron (TEM) respectively.
 Materials Methods: Nephron is completed passing through nephrogenic vesicles respected stages comma shape body, S-shape precapillary, ...

objective: diabetic nephropathy is a major diabetes complication. arterial resistance index (ri) may predict deterioration in kidney function. this study was designed to compare renal arterial ri in different stages of renal function according to glomerular filtration rate (gfr), serum creatinine level and proteinuria. materials and methods: in a cross-sectional study on 81 diabetic patients in...

Balkan endemic nephropathy (BEN) is a chronic tubulointerstitial kidney disease of unknown etiology. Not only the etiology of the disease but even the initial lesion, target nephron structure and morphogenesis remain unresolved. We have previously performed quantitative morphometric analysis on kidney biopsy specimens of patients in different stages of BEN (without renal failure, with initial a...

BACKGROUND Diabetes is a leading cause of chronic kidney disease (CKD). Whether reclassification of CKD stages based on glomerular filtration rate estimated using the CKD Epidemiology Collaboration (CKD-EPI) equation versus the Modification of Diet in Renal Disease (MDRD) Study equation modifies estimates of prevalent risk factors across stages is unknown. METHODS This is a cross-sectional an...

Examined fish of the genus Baryancistrus (Loricaridae) from Rio Xingu in central amazonian Brazil were found infected with extrasporogonic stages of Sphaerospora sp. (Myxosporea) in the blood and sporogonic stages in the glomeruli with the resulting escape of the sporogony products into the renal tubules, apparently when the mesangial tissue in the Bowman's capsule collapsed. Spores were seen e...

Understanding the pathogenesis of albuminuria in diabetic nephropathy is important to improve methods for early diagnosis and treatment. In this study, we addressed whether albuminuria in diabetes results from altered glomerular filtration and/or altered processing of filtered albumin by the proximal tubule. Type 1 diabetic Munich Wistar rats developed albuminuria after 12 wk of diabetes. Intra...

conclusions: in this study, kidney transplant recipients with a lower ri and pi and a higher edv at 1week showed better graft function at 6 months after transplantation. results: fourteen patients (15.4%) had impaired graft function after 6 months (gfr less than 60 ml/min/1.73m2). multivariate linear regression analysis showed significant correlation between gfr at 6 months and ri, pi and edv w...

abstract basement membrane of glomerular mesangium (bmg) is a thin membrane which helps to support the capillary loops in a renal glomerulus and type iv collagen is require for complete bm formation during glomerulogenesis. in this investigation specific antibody of type iv collagen has been used in light microscopy to study development of bmg of the embryonic and postnatal mouse glomerular mes...