The pathophysiology of Parkinson's disease is reviewed in light of recent advances in the understanding of the functional organization of the basal ganglia (BG). Current emphasis is placed on the parallel interactions between corticostriatal and corticosubthalamic afferents on the one hand, and internal feedback circuits modulating BG output through the globus pallidus pars interna and substant...

Although disorders of consciousness (DOCs) demonstrate widely varying clinical presentations and patterns of structural injury, global down-regulation and bilateral reductions in metabolism of the thalamus and frontoparietal network are consistent findings. We test the hypothesis that global reductions of background synaptic activity in DOCs will associate with changes in the pattern of metabol...

Recent investigations revealed mean diffusivity (MD) in gray matter and white matter areas is correlated with individual cognitive differences in healthy subjects and show unique properties and sensitivity that other neuroimaging tools donot have. In this study, we tested the hypothesis that the MD in the dopaminergic system is associated with individual differences in verbal creativity measure...

Grid computing aims at managing resources in a heterogeneous distributed environment. The Globus Toolkit provides a set of components that can be used to build applications that function in a grid computing system. Presently, applications are typically handcrafted either by using an Application Programming Interface (API) interacting through a set of command line interfaces, or by using a set o...

This tutorial is a practical introduction to programming for high-performance distributed computing systems, or "computational grids," and the capabilities of the Globus grid toolkit. Emerging high-performance networks promise to enable a wide range of emerging application concepts such as remote computing, distributed supercomputing, tele-immersion, smart instruments, and data mining. However,...

BACKGROUND/AIMS Globus is a persistent or intermittent non-painful sensation of a lump or foreign body in the throat. Given the benign nature of the condition and the association of gastroesophageal reflux disease, empirical therapy with proton pump inhibitor seems reasonable for patients with typical globus. The aim of this study was to investigate the clinical predictors for symptom response ...

The Globus Toolkit emerged among several projects as the standard de facto for the design of an infrastructure for computational grids. The Globus Security Infrastructure (GSI) provides security features that integrate and extend standard protocols for distributed systems with original solutions. In this paper we investigate the functional correctness and effectiveness of the GSI features with ...

After nigrostriatal dopaminergic denervation, the output nuclei of the basal ganglia, the medial globus pallidus and substantia nigra pars reticulata (Snr), become overactive, in part, because of increased activity of excitatory afferents from the subthalamic nucleus (STN). Because STN uses glutamate as a transmitter, we examined whether there are regulatory changes in glutamate receptor bindin...

In this paper we describe our work in progress to integrate the Shibboleth SAMLbased framework and Globus Toolkit’s PKIbased security infrastructure. The result will provide identity federation and attributebased policy enforcement for Grids that leverages the Shibboleth system being deployed on campuses. We provide an overview of both Shibboleth and the Globus Toolkit, present our motivating u...