Chemical imaging of single cells at the molecular level is important in capturing biological dynamics. Single cell correlative imaging is realized between super-resolution microscopy, namely, structured illumination microscopy (SIM), and time-of-flight secondary ion mass spectrometry (ToF-SIMS) using a multimodal microreactor (i.e., System for Analysis at the Liquid Vacuum Interface, SALVI). SI...

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FIB-based instruments play an ever more important role in materials science and also in life science. While such FIB-based instrumentation is an ideal tool for high resolution imaging (2D and 3D imaging) and nanofabrication (nanomaching, nanodeposition, specimen preparation), its analysis capability is currently limited. By contrast, Secondary Ion Mass Spectrometry (SIMS) is an extremely powerf...

The adsorption of bovine serum albumin (BSA), immunoglobulin G (IgG) and fibrinogen (Fgn) on fluorinated selfassembled monolayers have been studied using time of flight secondary ion mass spectrometry (ToF-SIMS) and Spectroscopic Ellipsometry (SE). The objective of the work has to establish the utility of ToF-SIMS for the determination of the amount of protein adsorbed on the surface. Quantific...

BACKGROUND Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) is a surface sensitive mass spectrometry technique with potential strengths as a method for detecting enzymatic activity on solid materials. In particular, ToF-SIMS has been applied to detect the enzymatic degradation of woody lignocellulose. Proof-of-principle experiments previously demonstrated the detection of both lignin-d...

A critical problem in building an information mediator is how to translate a domain-level queries into an e cient query plan for accessing the required data. We have built a exible and e cient information mediator, called SIMS. SIMS takes a domain-level query and dynamically selects the appropriate information sources based on their content and availability, generates a query access plan that s...

Objectives We developed a simple non-invasive I-123-N-isopropyl-p-iodoamphetamine (123I-IMP) quantification method by analyzing chest RI-angiography and single photon emission computed tomography (SPECT) images based on the microsphere model (SIMS method). Theoretically, the SIMS method could be changed to the simple non-invasive ARG (SIARG) method by modifying the integrated washout ratio (WR)...

Y. Tokita,†,‡,§ J. Hasegawa,† and H. Nakatsuji*,†,‡,| Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto UniVersity, Sakyo-ku, Kyoto 606-01, Japan, The Institute for Fundamental Chemistry, 34-4 Takano Nishi-Hiraki-cho, Sakyo-ku, Kyoto 606, Japan, Research Center, Denki Kagaku Kogyo Co., Ltd., 3-5-1 Asahimachi, Machida-shi Tokyo 194, Japan, and Department o...

The purpose of the present research was to translate into Spanish and analyze the psychometricA properties of the Situational Motivation Scale (SIMS). The participants were 373 undergraduate students (126 males and 247 females). Factor validity was tested via confirmatory factor analysis. Based on factor loadings and modification indexes, the SIMS was reduced to a 14-item model. This respecific...