Background The Gleason score is an essential tool in the decision to treat localized prostate cancer. However, experienced pathologists can classify Gleason score differently than do low-volume pathologists, and this may affect the treatment decision. This study sought to assess the impact of pathology review of external biopsy specimens from 23 men with a recent diagnosis of localized prostate...

for PSA failure ( P < 0.001; hazard ratio, HR, 2.6), need for salvage therapy ( P < 0.001; HR, 2.9) and specific deaths ( P = 0.006; HR, 3.7). The 5-year RFS was 84.4% in men with negative margins compared to 57.5% in the case of PSM. • After stratification by pathological stage and Gleason score, margin status was significantly predictive for PSA failure in pT2 ( P < 0.001), pT3a ( P = 0.001) ...

Background and Objective: Adenocarcinoma of the prostate is the second most common cause of cancer. The loss of CD10 is a common early event in human prostate cancer and is seen in lower Gleason Score malignancies while increased and altered expression is seen in high Gleason Score tumors, lymph nodes and bone metastasis. Material and Methods: This was a ...

this study was aimed at determining intra and inter-observer concordance rates in the gleason scoring of prostatic adenocarcinoma, before and after a web-based educational course. in this self-controlled study, 150 tissue samples of prostatic adenocarcinoma are re-examined to be scored according to the gleason scoring system. then all pathologists attend a free web-based course. afterwards, the...

BACKGROUND The aim of this study was to assess whether low serum testosterone levels in men with newly diagnosed prostate cancer have an association to the endocrine status, prostate-specific antigen (PSA) levels, Gleason score, and androgen receptor expression. METHODS Besides a full clinical work-up, the following hormones were quantified in men with newly diagnosed prostate cancer by serum...

In a previously published study, we showed that expression of the ABCD3 gene increased with increasing metastatic potential in a panel of prostate cancer cell lines derived from African American and Caucasian American men. Given importance of identifying biomarker(s) that can distinguish indolent versus aggressive prostate tumors, we conducted an immunohistochemical analysis of ABCD3 expression...

OBJECTIVES To evaluate how accurate a 12-core transrectal biopsy derived low-risk prostate cancer diagnosis is for an active surveillance programme by comparing the histological outcome with that from confirmatory transperineal sector biopsy. SUBJECTS AND METHODS The cohort included 166 men diagnosed with low volume Gleason score 3+3 prostate cancer on initial transrectal biopsy who also unde...

BACKGROUND Recognition of Gleason pattern 4 in prostatic needle biopsies is crucial for both prognosis and therapy. Recently, it has been recommended to record percent pattern 4 when Gleason score 7 cancer is the highest grade in a case. METHODS Four hundred and five prostate needle core biopsies received for a second opinion at our institution from February-June, 2015 were prospectively diag...